Age of Blood in Sickle Cell Transfusion

Completed · Phase 2/Phase 3

Conditions studied: Sickle Cell Disease

In brief

The Investigators hypothesize that older red cell units trigger phagocytosis and activation of circulating macrophages with a downstream immunomodulatory cascade and release of excess Non Transferrin Bound Iron(NTBI) that leads to increased rates of infection in adults with Sickle Cell Disease(SCD). To test this hypothesis, the study staff will perform a randomized prospective clinical trial. In aim 1, the study staff will determine the biochemical differences between ≥30 day-old versus ≤10 day-old units. In aim 2, the study staff will determine the physiologic effects of the transfused blood in a patient with SCD. Lastly, in aim 3, the study staff will explore the clinical implications of receiving older red cells over a 3 month period.

Key facts

Study ID

NCT03704922

Run by

University of North Carolina, Chapel Hill

People needed

26

Starts

2017-10-04

Expected to finish

2024-01-11

Last updated by the study team

2024-11-19

Who can join

Age: 16 and older, up to 60. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• age 16 to 60 years
• have diagnosis of sickle cell disease
• receiving outpatient red cell transfusion therapy
• outpatient at the time of transfusion

You may not qualify if…

• history of reactions to transfusion therapy that cannot be adequately managed by antihistamines
• do not have crossmatch compatible red cells
• participation in another therapeutic trial for SCD
• pregnant
• HIV positive
• uncontrolled inter-current illness, or psychiatric illness/social situations that would limit compliance with study requirements.

Where it is running

• Emory University — Atlanta, Georgia, United States
• University of North Carolina at Chapel Hill — Chapel Hill, North Carolina, United States
• Versiti Wisconsin — Milwaukee, Wisconsin, United States

Full record on ClinicalTrials.gov

Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.