Low-Fat Vegan Diet Versus a Mediterranean Diet on Body Weight

Completed · Not applicable

Conditions studied: Overweight, Obesity, Insulin Resistance

In brief

This randomized, cross-over trial aims to assess changes in body weight, plasma lipids, insulin sensitivity, and postprandial metabolism with a low-fat, plant-based diet and a Mediterranean diet, both followed for 4 months.

Key facts

Study ID

NCT03698955

Run by

Physicians Committee for Responsible Medicine

People needed

62

Starts

2018-10-22

Expected to finish

2019-11-13

Last updated by the study team

2024-09-27

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Men and women age ≥18 years of age
• Body mass index 28-40 kg/m2

You may not qualify if…

• Diabetes mellitus type 1, history of any endocrine condition that would affect body weight, such as thyroid disease, pituitary abnormality, or Cushing's syndrome
• Smoking during the past six months
• Alcohol consumption of more than 2 drinks per day or the equivalent, episodic increased drinking (e.g., more than 2 drinks per day on weekends), or a history of alcohol abuse or dependency followed by any current use
• Use of recreational drugs in the past 6 months
• Use within the preceding six months of medications that affect appetite or body weight, such as estrogens or other hormones, thyroid medications (unstable dose within the preceding 6 months), systemic steroids, antidepressants (tricyclics, MAOIs, SSRIs), antipsychotics, lithium, anticonvulsants, appetite suppressants or other weight-loss drugs, herbs for weight loss or mood, St. John's wort, ephedra, beta blockers
• Pregnancy or intention to become pregnant during the study period, as verified by self--- - Unstable medical or psychiatric illness
• Evidence of an eating disorder
• Likely to be disruptive in group sessions
• Already following a low-fat vegan diet or Mediterranean diet
• Lack of English fluency
• Inability to maintain current medication regimen
• Inability or unwillingness to participate in all components of the study
• Intention to follow another weight-loss method during the trial

Where it is running

• Physicians Committee for Responsible Medicine — Washington D.C., District of Columbia, United States

Full record on ClinicalTrials.gov

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