ECoG BMI for Motor and Speech Control

Recruiting now · Not applicable

Conditions studied: ALS, SCI - Spinal Cord Injury, Stroke, Multiple Sclerosis, Muscular Dystrophies

In brief

Test the feasibility of using electrocorticography (ECoG) signals to control complex devices for motor and speech control in adults severely affected by neurological disorders.

Key facts

Study ID

NCT03698149

Run by

Karunesh Ganguly

People needed

3

Starts

2018-11-09

Expected to finish

2030-08-15

Last updated by the study team

2026-05-05

Who can join

Age: 21 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Age \> 21
• Limited ability to use upper limbs, based on neurological examination, due to stroke, amyotrophic lateral sclerosis (ALS), multiple sclerosis, cervical spinal cord injury, brainstem stroke, muscular dystrophy, myopathy or severe neuropathy.
• Disability, defined by a 4 or greater score on the Modified Rankin Scale, must be severe enough to cause loss of independence and inability to perform activities of daily living.
• If stroke or spinal cord injury, at least 1 year has passed since onset of symptoms
• Must live within a two-hour drive of UCSF

You may not qualify if…

• Pregnancy or breastfeeding
• Inability to understand and/or read English
• Inability to give consent
• Dementia, based on history, physical exam, and MMSE
• Active depression (BDI \> 20) or other psychiatric illness (active general anxiety disorder, schizophrenia, bipolar disorder, obsessive-compulsive disorder (OCD), or personality disorders (e.g. multiple personality disorder, borderline personality disorder, etc.)
• History of suicide attempt or suicidal ideation
• History of substance abuse
• Co-morbidities including ongoing anticoagulation, uncontrolled hypertension, cancer, or major organ system failure
• Inability to comply with study follow-up visits
• Any prior intracranial surgery
• History of seizures
• Immunocompromised
• Has an active infection
• Has a CSF drainage system or an active CSF leak
• Requires diathermy, electroconvulsive therapy (ECT), or transcranial magnetic stimulation (TMS) to treat a chronic condition
• Has an implanted electronic device such as a neurostimulator, cardiac pacemaker/defibrillator or medication pump, or presence of any head or neck metallic foreign bodies
• Allergies or known hypersensitivity to materials in the Blackrock NeuroPort Array (i.e. silicone, titanium) or the PMT Subdural Cortical Electrode (silicone, platinum iridium, nichrome)

Where it is running

• University of California San Francisco — San Francisco, California, United States (enrolling)

Full record on ClinicalTrials.gov

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