A Pilot Trial of Disposable Nitrous Oxide Canisters in Providing Pain Control During Burn Dressing Changes

Recruiting now · Early Phase 1 · Has a placebo group

Conditions studied: Burns, Pain, Acute

In brief

Improvements in burn care have resulted in increased survival. Despite these improved outcomes one of the leading challenges of burn care remains providing adequate analgesia during routine wound care and dressing changes. The traditional use of narcotics is challenging as the therapeutic window between analgesia and suppression of breathing becomes narrow with the intense pain and high doses of narcotics needed for dressing changes.

Key facts

Study ID

NCT03695887

Run by

University of Manitoba

People needed

30

Starts

2019-10-01

Expected to finish

2029-12-01

Last updated by the study team

2026-05-14

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• adult burn patients admitted to the Health Sciences Centre
• total body surface area burned of 5-20%

You may not qualify if…

• admitted to intensive care unit
• unable to participate in the measurement outcomes (sedated, cognitively impaired, unable to understand English or visually impaired)
• medical condition that precludes using nitrous oxide (respiratory disease and significant cardiovascular disease 5).
• pregnant
• physically unable to hold the canister
• <90% SaO2 on room air
• face burn
• pre-injury narcotics (relative exclusion)
• use of IV ketamine
• pre-existing lung injury

Where it is running

• University of Manitoba — Winnipeg, Manitoba, Canada (enrolling)

Full record on ClinicalTrials.gov

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