Developing Viability Index for Machine Perfused Livers

Recruiting now · Not applicable

Conditions studied: Liver Cirrhoses

In brief

Machine perfusion technology is nearing the point of rescuing discarded liver grafts in the hope of proving them to be or improving them to the point of being transplantable. However, there are no validated metrics to determine transplantability after machine perfusion. This study involves collecting biopsies from transplanted livers before and after implantation to correlate metabolite and gene expression with post-transplant function. This data will help develop a viability index for machine perfused livers.

Key facts

Study ID

NCT03694691

Run by

Massachusetts General Hospital

People needed

60

Starts

2018-10-01

Expected to finish

2030-06-01

Last updated by the study team

2025-11-03

Who can join

Age: 18 and older, up to 75. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Male or female 18-75 years of age.
• Candidate for a deceased-donor liver allograft.

You may not qualify if…

• Seropositivity for HIV-1.

Where it is running

• Massachusetts General Hospital — Boston, Massachusetts, United States (enrolling)

Full record on ClinicalTrials.gov

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