A Study of IMMray™ PanCan-d Test for Early Detection of Pancreatic Cancer in High-risk Groups

Completed

Conditions studied: Pancreatic Ductal Adenocarcinoma, Familial Pancreatic Cancer, FAMMM - Familial Atypical Mole Malignant Melanoma Syndrome

In brief

PanFAM-1 is a clinical study for early detection of pancreatic cancer in high-risk groups. The goals of the study are to assess the performance and diagnostic accuracy of the IMMray™ PanCan-d test compared to standard-of-care imaging.

Key facts

Study ID

NCT03693378

Run by

Immunovia, Inc.

People needed

1349

Starts

2016-01-19

Expected to finish

2021-11-12

Last updated by the study team

2022-03-31

Who can join

Age: any. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Ability to understand and the willingness to sign a written informed consent document
• Individuals with the following family phenotype and age:
• Two or more relatives with pancreatic adenocarcinomas (PDAC) on the same side of the family, where two PDAC-affected individuals are first degree related (FDR) + at least one PDAC-affected individual is a FDR of the Participant (≥50 years old OR 10 years before onset in family)
• Two affected FDR with PDAC (≥50 years old OR 10 years before onset of an FDR)
• Any of BRCA1, BRCA2, PALB2, ATM mutations confirmed pathogenic or likely pathogenic + one FDR or secondary degree related (SDR) with PDAC (≥50 years old OR 10 years before onset of an FDR and SDR)
• Familial atypical multiple mole-melanoma (FAMMM) with confirmed pathogenic or likely pathogenic mutation variants in: p16, CDKN2A (≥50 years old)
• Known mutation carrier for STK11 (Peutz Jeghers Syndrome) (≥35 years old)
• Lynch syndrome (HNPCC) with confirmed pathogenic or likely pathogenic variants in: MLH1, MSH2, MSH6, PMS2, or EPCAM + one FDR or SDR with PDAC (≥50 years old OR 10 years before onset of an FDR or SDR)
• Hereditary pancreatitis with confirmed PRSS1 pathogenic or likely pathogenic history of pancreatitis (≥40 years old)

You may not qualify if…

• None

Where it is running

• Stanford Gastroenterology and Hepatology — Stanford, California, United States
• Yale University — New Haven, Connecticut, United States
• University of Chicago Medical Center — Chicago, Illinois, United States
• Massachusetts General Hospital — Boston, Massachusetts, United States
• University of Massachusetts — Worcester, Massachusetts, United States
• New York University Hospital — New York, New York, United States
• Columbia University — New York, New York, United States
• Mount Sinai Hospital — New York, New York, United States
• The Ohio State University — Columbus, Ohio, United States
• Oregon Health & Science University — Portland, Oregon, United States
• University of Pennsylvania — Philadelphia, Pennsylvania, United States
• University of Pittsburgh Medical Center — Pittsburgh, Pennsylvania, United States
• University of Utah — Salt Lake City, Utah, United States
• The Research Institute of the McGill University Health Centre — Montreal, Canada
• University Hospital Ramon y Cajal — Madrid, Spain
• University Hospital Santiago De Compostela — Santiago de Compostela, Spain
• Sahlgrenska University Hospital — Gothenburg, Sweden
• Linköping University Hospital — Linköping, Sweden
• Karolinska University Hospital — Stockholm, Sweden
• Umeå University Hospital — Umeå, Sweden
• University Collage London Hospital — London, United Kingdom

Full record on ClinicalTrials.gov

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