Influence of Early Menopause on Sympathetic Activation and Cardiovascular Function in Older Women

Completed · Not applicable · Has a placebo group

Conditions studied: Early Menopause, Menopause

In brief

Women who enter menopause early are at a greater risk for developing cardiovascular disease later in life as compared to women with normal onset of menopause. This increased risk may be due to a prolonged length of time with decreased hormone levels post-menopause; however, this health risk remains understudied. The current study plan to study why women with early menopause are at higher risk for cardiovascular disease by evaluating their sympathetic nervous system and heart-blood vessel function. In addition, there is lack of promising treatment plans for cardiovascular disease in post-menopausal women. Therefore, the current study will also test the impact of dietary nitrate on post-menopausal women to determine if it might serve as a potential treatment to reduce risk of cardiovascular disease in older women.

Key facts

Study ID: NCT03692572
Run by: University of Texas Southwestern Medical Center
People needed: 22
Starts: 2018-08-01
Expected to finish: 2021-12-31
Last updated by the study team: 2024-06-12

Who can join

Age: 60 and older, up to 70. Sex: female. Healthy volunteers: accepted.

You may qualify if…

Healthy normotensive postmenopausal women
Current age between 60 and 70 years
Who have experienced "natural" or non-surgical menopause

You may not qualify if…

Any evidence of cardiopulmonary disease
History of hormone replacement therapy in the last 5 years
Chronic kidney disease
Diabetes mellitus
Hypertension
Current abuse of alcohol or drugs and use of tobacco products
Surgical procedure induced menopause

Where it is running

Institute for Exercise and Environmental Medicine — Dallas, Texas, United States

Full record on ClinicalTrials.gov

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