Daytime Bright Light, Circadian Abnormalities, and Delirium in Medical ICU Patients

Completed · Not applicable

Conditions studied: Circadian Rhythm Disorders

In brief

To determine if daytime bright light will promote circadian alignment and shorten or prevent delirium.

Key facts

Study ID

NCT03684460

Run by

Yale University

People needed

68

Starts

2019-07-08

Expected to finish

2024-03-28

Last updated by the study team

2024-05-23

Who can join

Age: 50 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Hospital admission ≤30 hours at noon on enrollment day
• Expected to say in the Medical Intensive Care Unit (MICU) ≥24 hours after enrollment
• Age ≥50 years

You may not qualify if…

• At significant risk for pre-existing circadian abnormalities:
• Severe chronic brain injury (Injury greater than 30 days ago resulting in the inability to live independently)
• Acute brain injury of any severity (Injury less than 30 days ago including acute intracranial bleed, traumatic brain injury, central nervous system infection, tumor)
• Documented circadian disorder or blind/disease of the optic nerve
• Current history of substance abuse including alcohol (use in last 30 days)
• Transferred from an outside hospital. 4. History of bipolar disease 5. Paralyzed (due to injury, disease or medications)
• Enrolled patients who do not stay in the MICU through 13:00 of Study Day 2 will be excluded; patients transferred from the MICU to the floor between 22:00 and 05:00 on subsequent study nights will continue in the study but be excluded from the primary analysis (estimated 10% of patients).

Where it is running

• Yale New Haven Hospital, York Street Campus — New Haven, Connecticut, United States

Full record on ClinicalTrials.gov

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