Identifying Novel Aging Targets for Treatment of Delirium

Stopped early

Conditions studied: Delirium, Dementia Alzheimers, Respiratory Failure

In brief

The long-term goal of this research program is to improve understanding of the mechanistic link between Alzheimer's disease (AD) neuropathology, acute delirium, and cognitive impairment following acute respiratory failure. In this pilot study, the study team will establish a prospective cohort of older patients with acute respiratory failure and obtain data on delirium duration, AD imaging and CSF biomarkers, and cognitive outcomes following critical illness.

Key facts

Study ID

NCT03682874

Run by

Wake Forest University Health Sciences

People needed

5

Starts

2018-10-10

Expected to finish

2020-02-20

Last updated by the study team

2021-06-30

Who can join

Age: 55 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Age greater than or equal to 55 years
• Anticipated ICU stay of at least 48 hours
• Delirium during ICU stay defined as CAM-ICU positive on at least two occasions at least 12 hours apart within 72 hours.

You may not qualify if…

• Diagnosis of dementia in electronic medical record at time of ICU admission
• Blindness, deafness, or inability to understand English as this prevents ICU delirium assessment
• Cognitive impairment prior to hospitalization (inability to follow instructions/comply with study/sign consent)
• Score of > 3.30 on Informant Questionnaire of Cognitive -Decline in the Elderly (IQCODE)[34]. Questionnaire will be given to family member or legally authorized representative.
• Pregnancy/lactating/breastfeeding
• Legally incapacitated: Prisoner/Ward of State
• History of prior large vessel cerebrovascular accident (CVA)
• History of neurologic disorder prior to ICU admission including multiple sclerosis, Parkinson disease, epilepsy, amyotrophic lateral sclerosis (ALS), Guillain-Barre Syndrome (GBS)
• Psychiatric illness including schizophrenia, bipolar disorder, depression with psychotic features
• Not expected to survive 24 hours
• Judgment of investigator that subject participation could jeopardize subject health/safety or integrity of study
• Active malignancy requiring treatment in the prior 6 months
• Inability to return for study procedures
• Inability to obtain consent

Where it is running

• Wake Forest Baptist Health — Winston-Salem, North Carolina, United States

Full record on ClinicalTrials.gov

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