Validating a New Non-invasive Approach to Testing Lidocaine Effectiveness

Completed · Early Phase 1 · Has a placebo group

Conditions studied: ADHD, Controls

In brief

This work will assess the reliability of a simple painless test for the effectiveness of the commonly used local anesthetic lidocaine

Key facts

Study ID

NCT03680885

Run by

PhenoSolve, LLC

People needed

20

Starts

2019-08-01

Expected to finish

2020-03-30

Last updated by the study team

2020-07-15

Who can join

Age: 18 and older, up to 49. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Report "get numb at dentist"

You may not qualify if…

• ADHD, ADD, and other inattention disorders
• Known adverse reactions to lidocaine;
• Epilepsy
• IQ <80
• Severe head trauma
• Birth weight <2270 grams
• Severe autism
• Generalized anxiety disorders (but dental-specific anxiety will not be an exclusion because many of these individuals may be ones with anxiety because of painful dental experiences with lidocaine ineffectiveness)
• Mouth sores
• Ehlers Danlos syndrome
• Red hair
• Current pregnancy
• Treatment currently with potassium or potassium-elevating drugs such as renin-angiotensin-aldosterone blockers
• Angiotensin Converting Enzyme Inhibitors
• Alacepril (not available in US)
• Benazepril (Lotensin)
• Captopril (trade name Capoten)
• Cilazapril (Inhibace)
• Delapril (not available in US)
• Enalapril (Vasotec/Renitec)
• Fosinopril (Fositen/Monopril)
• Imidapril (Tanatril)
• Lisinopril (Listril/Lopril/Novatec/Prinivil/Zestril)
• Moexipril (Univasc)
• Perindopril (Coversyl/Aceon/Perindo)

Where it is running

• Jacobi Medical Center — The Bronx, New York, United States

Full record on ClinicalTrials.gov

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