Accelerated Theta Burst in Treatment-Resistant Depression: A Dose Finding and Biomarker Study

Completed · Not applicable

Conditions studied: Treatment Resistant Depression

In brief

This study evaluates the effectiveness of re-treatment using accelerated schedule of intermittent theta-burst stimulation for treatment-resistant depression. This is an open label study.

Key facts

Study ID

NCT03680781

Run by

Stanford University

People needed

40

Starts

2018-04-13

Expected to finish

2024-12-02

Last updated by the study team

2026-07-22

Who can join

Age: 18 and older, up to 75. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Male or female, 18 to 75 years of age.
• Able to provide informed consent.
• Diagnosed with Major Depressive Disorder (MDD) or bipolar affective disorder 2 and currently experiencing a Major Depressive Episode (MDE).
• prior exposure to rTMS
• Participants must qualify as "moderate or severe treatment refractory" using the Maudsley staging method.
• Participants may continue antidepressant regimen, but must be stable for 6 weeks prior to enrollment in the study. They must maintain that same antidepressant regimen throughout the study duration.
• Participants are required to have a stable psychiatrist for the duration of study enrollment.

You may not qualify if…

• History of MI, CABG, CHF, or other cardiac history
• Any neurological conditions
• History of epilepsy
• OCD
• Independent sleep disorder
• Autism Spectrum Disorder

Where it is running

• Department of Psychiatry and Behavioral Sciences, Stanford School of Medicine — Palo Alto, California, United States

Full record on ClinicalTrials.gov

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