Comparison of Three Opioid Detoxification Treatment Regimens

Withdrawn before enrolling · Phase 3

Conditions studied: Opioid-Related Disorders, Opioid Withdrawal

In brief

Despite an increased focus on treating opioid use disorder there are relatively few studies that compare the length of time required for detoxification with medications other than buprenorphine. Morphine and tramadol have shorter half-lives than buprenorphine and can be used for opioid detoxification. The proposed protocol aims to address this gap by directly comparing the length of treatment required for detoxification from opioids in a patient-centered manner with oral morphine, tramadol, or buprenorphine-naloxone as well as comparing the severity of withdrawal experienced by patients in each group. The investigators predict that treatment with oral morphine or tramadol will result in a faster completion of detoxification and initiation of naltrexone maintenance.

Key facts

Study ID

NCT03678792

Run by

University of Alabama at Birmingham

People needed

0

Starts

2019-11-15

Expected to finish

2020-10-25

Last updated by the study team

2019-11-05

Who can join

Age: 18 and older, up to 65. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• 18-65 years of age
• Meeting DSM-V criteria for opioid use disorder
• Current use of opiates
• Displaying evidence of opioid withdrawal
• Having no significant current medical/psychiatric illness
• English speaking

You may not qualify if…

• Use of methadone or buprenorphine exclusively
• Pregnancy
• Hypotensive
• History of seizures
• Physical dependence on alcohol and/or benzodiazepines that requires treatment

Where it is running

• Virginia Commonwealth University — Richmond, Virginia, United States

Full record on ClinicalTrials.gov

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