Acute Renal Injury During High Intensity Training

Completed · Not applicable

Conditions studied: Acute Kidney Injury, Exercise

In brief

The proposed work is designed to be the first in a series of studies investigating the health benefits and risks related to high intensity training (HIT) exercise. Our specific aims are to determine, 1) if participation in a single bout of HIT induces hematological markers consistent with acute kidney injury (AKI), and 2) if risk is predicted by the pre-exercise concentration of plasma proenkephalin-A. This investigation is an observational case control study. In year one, data collection procedures will be refined with \~40 participants local to the University of Wyoming and training will occur for collaborators from Wyoming community and tribal colleges. In year two, data collection will expand to some of the 12 CrossFit® gyms in Wyoming with assistance from the community and tribal colleges. Blood and urine samples will be collected before and up to 48 h after a standardized bout of HIT exercise on \~100 participants. Baseline blood samples will be analyzed for proenkephalin-A. All blood samples will be analyzed for markers of muscle damage (e.g., creatine kinase and myoglobin), and markers of kidney function (e.g., serum creatinine and blood urea nitrogen). Urine will be analyzed for markers of filtration function (e.g., albumin, creatinine, neutrophil gelatinase-associated lipocalin \[NGAL\], and kidney injury molecule 1 \[KIM-1\]). Lastly, the severity of kidney damage will be compared with the number of risk alleles and proenkephalin-A concentration. The investigators envision that the bout of HIT exercise will induce markers consistent with skeletal muscle damage in most participants and, based on literature from other styles of intense exercise, that acute kidney injury will be diagnosable in between 50-75% of participants. Secondarily, the investigators predict that the concentration of proenkephalin-A will be inversely related to the change in kidney function from before to after the HIT exercise bout.

Key facts

Study ID

NCT03678285

Run by

University of Wyoming

People needed

42

Starts

2018-10-01

Expected to finish

2019-06-30

Last updated by the study team

2021-07-16

Who can join

Age: 18 and older, up to 60. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Healthy individual who has completed this specific workout on at least one prior occasion

You may not qualify if…

• Score of "0" on the Functional Movement Screening (FMS) test as evaluated by two investigators * indicating pain during any of the seven functional movements
• Self- reported Kidney (chronic kidney disease, polycystic kidney disease, glomerulonephritis, diabetic nephropathy, interstitial nephritis, Goodpasture syndrome) or other medical condition contraindicating participation in HIFRT (Hypertension, dyslipidemia, type II diabetes mellitus, BMI >30)
• Pregnancy, suspected pregnancy, or breastfeeding
• Blood donations within the last eight weeks leading up to testing day
• Any musculoskeletal injuries which have resulted in > 1 week of absence from HIFRT within the last six months
• Not passing the physical activity readiness questionnaire (PAR-Q)
• Allergy to ibuprofen or non-steroidal anti-inflammatory medication
• Surgical operation on digestive tract or kidneys, except appendectomy
• Inability to participate in the entire study
• Recurrent urinary tract infections or kidney stones
• History of protein or blood in urine
• Moving from a location of low altitude (< 3,000') to Laramie within the past 3 months
• Inability to understand and write English

Where it is running

• University of Wyoming — Laramie, Wyoming, United States

Full record on ClinicalTrials.gov

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