A Phase III Study to Evaluate the Port Delivery System With Ranibizumab Compared With Monthly Ranibizumab Injections in Participants With Wet Age-Related Macular Degeneration

Completed · Phase 3

Conditions studied: Neovascular Age-Related Macular Degeneration

In brief

Study GR40548 is a Phase III, randomized, multicenter, open-label (visual assessor \[VA\]-masked), active-comparator study designed to assess the efficacy, safety, and pharmacokinetics (PK) of 100mg/ml delivered via the Port Delivery System with ranibizumab (PDS) compared with ranibizumab intravitreal injections at 0.5 mg (10 mg/mL) in participants with neovascular age-related macular degeneration (nAMD).

Key facts

Study ID

NCT03677934

Run by

Hoffmann-La Roche

People needed

415

Starts

2018-09-12

Expected to finish

2021-06-09

Last updated by the study team

2022-10-04

Who can join

Age: 50 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Age ≥50 years, at time of signing Informed Consent Form
• Initial diagnosis of exudative neovascular age-related macular degeneration (nAMD) within 9 months prior to the screening visit
• Previous treatment with at least three anti-vascular endothelial growth factor (anti-VEGF) intravitreal injections for nAMD per standard of care within 6 months prior to the screening visit
• Demonstrated response to prior anti-VEGF intravitreal treatment since diagnosis
• Best-corrected visual acuity (BCVA) of 34 letters or better

You may not qualify if…

• Subfoveal fibrosis or subfoveal atrophy in study eye
• Subretinal hemorrhage that involves the center of the fovea in study eye
• History of vitrectomy surgery, submacular surgery, or other surgical intervention for AMD in study eye
• Prior treatment with Visudyne®, external-beam radiation therapy, or transpupillary thermotherapy in study eye
• Previous intraocular device implantation in study eye
• Previous laser (any type) used for AMD treatment in study eye
• Treatment with anti-VEGF agents other than ranibizumab within 1 month prior to the randomization visit in either eye
• Prior participation in a clinical trial involving anti-VEGF drugs within 6 months prior to the randomization visit, other than ranibizumab in either eye
• CNV due to other causes, such as ocular histoplasmosis, trauma, or pathologic myopia in either eye
• Uncontrolled blood pressure
• History of stroke within the last 3 months prior to informed consent
• Uncontrolled atrial fibrillation within 3 months of informed consent
• History of myocardial infarction within the last 3 months prior to informed consent
• History of other disease, metabolic dysfunction, or clinical laboratory finding giving reasonable suspicion of a disease or condition that contraindicates the use of ranibizumab or placement of the Implant and that might affect interpretation of the results of the study or renders the participant at high risk of treatment complications in the opinion of the investigator
• Current systemic treatment for a confirmed active systemic infection
• Chronic use of oral corticosteroids
• Active cancer within 12 months of randomization
• Previous participation in any non-ocular (systemic) disease studies of investigational drugs within 1 month preceding the informed consent (excluding vitamins and minerals)

Where it is running

• Associated Retina Consultants — Phoenix, Arizona, United States
• Arizona Retina and Vitreous Consultants — Phoenix, Arizona, United States
• Retinal Consultants of Arizona — Phoenix, Arizona, United States
• California Retina Consultants — Bakersfield, California, United States
• Retina-Vitreous Associates Medical Group — Beverly Hills, California, United States
• The Retina Partners — Encino, California, United States
• Jules Stein Eye Institute/ UCLA — Los Angeles, California, United States
• N CA Retina Vitreous Assoc — Mountain View, California, United States
• Retina Consultants, San Diego — Poway, California, United States
• Retinal Consultants Med Group — Sacramento, California, United States
• West Coast Retina Medical Group — San Francisco, California, United States
• UCSF; Ophthalmology — San Francisco, California, United States
• Orange County Retina Med Group — Santa Ana, California, United States
• California Retina Consultants — Santa Barbara, California, United States
• Bay Area Retina Associates — Walnut Creek, California, United States
• Southwest Retina Consultants — Durango, Colorado, United States
• Eye Center of Northern CO — Fort Collins, Colorado, United States
• Colorado Retina Associates, PC — Lakewood, Colorado, United States
• Retina Group of New England — Waterford, Connecticut, United States
• National Ophthalmic Research Institute — Fort Myers, Florida, United States
• Florida Eye Associates — Melbourne, Florida, United States
• Retina Care Specialists — Palm Beach Gardens, Florida, United States
• Retina Specialty Institute — Pensacola, Florida, United States
• Fort Lauderdale Eye Institute — Plantation, Florida, United States
• Barnet Dulaney Perkins Eye Center — Mesa, Arizona, United States

Full record on ClinicalTrials.gov

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