Exercise Training Effects on Cognition and Brain Function in Multiple Sclerosis: Project EXACT

Completed · Not applicable

Conditions studied: Multiple Sclerosis, Cognitive Impairment

In brief

Cognitive impairment is highly prevalent, poorly-managed, and disabling in persons with MS and exercise training might represent a promising approach to manage this symptom of the disease. The proposed study aims to examine the effects of 3-months of supervised, progressive (both intensity and duration) treadmill walking exercise training (designed based on pilot work and American College of Sports Medicine guidelines) compared with an active control condition (i.e., stretching-and-toning activities) on cognitive processing speed and functional MRI outcomes in 88 cognitively-impaired persons with MS. This study is critical for providing evidence supporting treadmill walking exercise training as a behavioral approach for managing slowed cognitive processing speed (i.e., the most common MS-related cognitive impairment) and improving brain health in persons with MS.

Key facts

Study ID
NCT03677440
Run by
Kessler Foundation
People needed
43
Starts
2019-02-05
Expected to finish
2024-12-31
Last updated by the study team
2025-06-05

Who can join

Age: 18 and older, up to 65. Sex: any. Healthy volunteers: not accepted.

Where it is running

Full record on ClinicalTrials.gov

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