Trial of Mosunetuzumab (BTCT4465A) as Consolidation Therapy in Participants With Diffuse Large B-Cell Lymphoma Following First-Line Immunochemotherapy and as Monotherapy or in Combination With Polatuzumab Vedotin in Elderly/Unfit Participants With Previously Untreated Diffuse Large B-Cell Lymphoma
Completed · Phase 1/Phase 2
Conditions studied: Diffuse Large B-cell Lymphoma
In brief
This study will evaluate the safety, pharmacokinetics, and preliminary efficacy of mosunetuzumab following first-line diffuse large B-cell lymphoma (DLBCL) immunochemotherapy in participants with a best response of stable disease or partial response, or in elderly/unfit participants with previously untreated DLBCL, or subcutaneous mosunetuzumab in combination with polatuzumab vedotin IV in elderly/unfit participants with previously untreated DLBCL.
Key facts
- Study ID
- NCT03677154
- Run by
- Hoffmann-La Roche
- People needed
- 188
- Starts
- 2019-05-23
- Expected to finish
- 2025-08-07
- Last updated by the study team
- 2025-08-21
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
Where it is running
- University of Alabama at Birmingham School of Medicine — Birmingham, Alabama, United States
- University of California, Los Angeles (UCLA) - Hematology/Oncology Santa Monica — Santa Monica, California, United States
- Fort Wayne Medical Institute — Fort Wayne, Indiana, United States
- University of Maryland Medical Center — Baltimore, Maryland, United States
- Duke University — Durham, North Carolina, United States
- Fox Chase Cancer Center — Philadelphia, Pennsylvania, United States
- Rhode Island Hospital — Providence, Rhode Island, United States
- Texas Oncology - Baylor Charles A. Sammons Cancer Center — Dallas, Texas, United States
- Soroka Medical Center — Beersheba, Israel
- Rambam Medical Center — Haifa, Israel
- Carmel medical center — Haifa, Israel
- Shaare Zedek Medical Center — Jerusalem, Israel
- Hadassah Ein-Karem — Jerusalem, Israel
- Meir Medical Center — Kfar Saba, Israel
- Sheba Medical Center — Ramat Gan, Israel
- Uniwersyteckie Centrum Kliniczne — Gdansk, Poland
- PRATIA MCM Kraków — Krakow, Poland
- Centrum Onkologii Ziemi Lubelskiej im. ?w. Jana z Dukli — Lublin, Poland
- Szpital Wojewodzki w Opolu — Opole, Poland
- Pusan National University Hospital — Busan, South Korea
- Keimyung University Dongsan Hospital — Daegu, South Korea
- Samsung Medical Center — Seoul, South Korea
- The Catholic University of Korea Yeouido St. Mary's Hospital — Seoul, South Korea
- Seoul National University Hospital — Seoul, South Korea
- Severance Hospital, Yonsei University — Seoul, South Korea
Full record on ClinicalTrials.gov
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