Biology of Cerebral Arteriovenous Malformations and Prognosis of Cerebral Arteriovenous Malformations

Recruiting now

Conditions studied: Cerebral Arteriovenous Malformations, Ruptured or Unruptured Cerebral Arteriovenous Malformations

In brief

The cerebral arteriovenous malformations correspond to the formation of an entanglement of morphologically abnormal vessels called nidus, which shunt the blood circulation directly from the arterial circulation to the venous circulation. The cerebral arteriovenous malformations are an important cause of hemorrhagic stroke. The hypothesis is that cerebral haemorrhage associated with a cerebral arteriovenous malformations would come from peri-nidal micro-vessels, in connection with infiltration of leucocytes and / or defective maintenance of microvascular integrity by platelets.

Key facts

Study ID

NCT03676868

Run by

Fondation Ophtalmologique Adolphe de Rothschild

People needed

300

Starts

2018-11-20

Expected to finish

2028-11-19

Last updated by the study team

2025-06-25

Who can join

Age: any. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Patient over 18 years old
• Patient with a cerebral AVM for which an intervention (endovascular treatment or surgery) or only clinical monitoring
• Express consent to participate in the study
• And
• children
• Free informed and express consent of both holders of the minor patient's parental authority, or, by way of derogation and only if the other holder of parental authority cannot give his or her consent within a time limit compatible with the methodological requirements specific to the conduct of the research with regard to its purposes, of one of the two holders of parental authority

You may not qualify if…

• Patient benefiting from a legal protection measure
• Pregnant or breast feeding woman

Where it is running

• Fondation Ophtalmologique Rotschild — Paris, France (enrolling)

Full record on ClinicalTrials.gov

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