Cohort Study of Risk Factors for Postoperative Cognitive Decline

Completed

Conditions studied: Cognitive Decline

In brief

Presently, the role of either genetic factors or biological sex in the development of postoperative cognitive dysfunction (POCD) is unknown. There is a critical need to determine which individuals are at high-risk for developing POCD by virtue of biological sex or genetic predisposition. The knowledge gained in the described research has the potential to shed light on mechanistic pathways, a necessary next step in order to ultimately identify therapeutic strategies.

Key facts

Study ID

NCT03676738

Run by

Oregon Health and Science University

People needed

125

Starts

2018-03-26

Expected to finish

2022-05-20

Last updated by the study team

2022-05-26

Who can join

Age: 65 and older, up to 89. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Scheduled for an in-patient, elective spine surgery where subject will receive general anesthesia
• Presenting to spine clinic and undergoing conservative, non-surgical management of spine disorder
• Subjects must have sufficient vision and hearing to complete neuropsychological testing
• Proficient in spoken and written English language

You may not qualify if…

• Diagnosed dementia or dementia-related treatment (i.e. donepezil prescription, or memory-care facility residence)
• Significant disease of the central nervous system (CNS) (i.e. Parkinson's disease)
• History of stroke or traumatic brain injury
• Major psychiatric disorder (i.e. schizophrenia)
• Alcohol or drug abuse according to DSM-V within the last 2 years
• Need for urgent/emergent surgery
• Surgery/anesthesia within prior 12 months
• Refusal of consent

Where it is running

• OHSU — Portland, Oregon, United States

Full record on ClinicalTrials.gov

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