Caffeine Consumption in Glaucoma Patients and Healthy Subjects

Recruiting now · Not applicable

Conditions studied: Glaucoma, Primary Open Angle

In brief

Caffeine is the most widely consumed drinking nutrient in the world. Caffeine effects various organs and the vascular system. It decreases ocular blood flow due to vasoconstriction.

Key facts

Study ID

NCT03675412

Run by

Wills Eye

People needed

80

Starts

2018-12-30

Expected to finish

2026-12-31

Last updated by the study team

2025-11-14

Who can join

Age: 18 and older, up to 90. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• age 18 to 90 years
• diagnosis of primary open angle glaucoma (Mild, Moderate and Advanced)
• healthy subjects with no eye disease

You may not qualify if…

• Diseases, ophthalmic or systemic, that are likely to affect OCTA results
• greater than moderate cataract
• nystagmus
• inability to look at target
• macular degeneration other than mild drusen or pigmentary changes
• diabetic retinopathy
• neovascular glaucoma or non-glaucoma optic neuropathies
• current macular edema, prior laser to retina, inflammatory retinopathy or choroidopathy
• keratoconus, corneal ectasia, central corneal scarring
• rheumatologic diseases or Raynaud's phenomena
• pregnant and lactating women
• mental illness or alcohol addiction
• pre-existing bladder symptoms, cardiac disease or sleep disorder
• refractive spherical diopter greater than 5 or cylinder greater than 3
• possible tolerance to caffeine (drinking more than 1 cup coffee per day).

Where it is running

• Wills Eye Glaucoma Service — Philadelphia, Pennsylvania, United States (enrolling)

Full record on ClinicalTrials.gov

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