Screening for Asymptomatic Coronary Artery Disease in Kidney Transplant Candidates

Running, not enrolling · Not applicable

Conditions studied: Cardiovascular Diseases, End Stage Renal Disease, Kidney Transplantation, Dialysis Related Complication

In brief

The Canadian Australasian Randomized Trial of Screening Kidney Transplant Candidates for Coronary Artery Disease (CARSK) will test the hypothesis that eliminating the regular use of non-invasive screening tests for CAD AFTER waitlist activation is not inferior to regular (i.e., annual) screening for CAD during wait-listing for the prevention of Major Adverse Cardiac Events. Secondary analyses will assess the impact of screening on the rate of transplantation, and the relative cost-effectiveness of screening.

Key facts

Study ID

NCT03674307

Run by

University of British Columbia

People needed

3306

Starts

2018-12-01

Expected to finish

2028-01-26

Last updated by the study team

2026-07-06

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• adults aged 18 years of age or older
• Dialysis-dependent kidney failure and currently being assessed for OR active on the kidney transplant waiting list
• expected to require further screening for CAD prior to transplantation (by current standard of care);
• able to give consent;
• anticipated to undergo transplantation more than 12 months from date of enrolment

You may not qualify if…

• patients with signs or symptoms suggestive of uncontrolled cardiac disease such as unstable coronary syndromes, decompensated heart failure, uncontrolled arrhythmia, and severe valvular heart disease;
• patients who "on-hold" for transplantation due to a medical problem;
• patients with other solid organ transplants;
• multi-organ transplant candidates (e.g. kidney-pancreas transplant candidates);
• patients with planned living donor transplant;
• patients unable to give consent.

Where it is running

• University of Arizona — Tucson, Arizona, United States
• The George Washington University — Washington D.C., District of Columbia, United States
• University of Alberta — Edmonton, Alberta, Canada
• University of British Columbia — Vancouver, British Columbia, Canada
• Dalhousie University — Halifax, Nova Scotia, Canada
• St. Joseph's Healthcare — Hamilton, Ontario, Canada
• Kingston Health Science Centre — Kingston, Ontario, Canada
• London Health Science Centre — London, Ontario, Canada
• The Ottawa Hospital Research Institute — Ottawa, Ontario, Canada
• University Health Network — Toronto, Ontario, Canada
• St Michael's Hospital — Toronto, Ontario, Canada
• CHU de Quebec-Universite Laval's L'Hotel-Dieu de Quebec — Laval, Quebec, Canada
• University of Montreal, Maisonneuve-Rosemont Hospital — Montreal, Quebec, Canada
• McGill University Health Centre — Montreal, Quebec, Canada
• Universite de Montreal, Hopital Maisonneuve-Rosemont — Montreal, Quebec, Canada
• St. Paul's Hospital, University of Saskatchewan — Saskatoon, Saskatchewan, Canada
• Charité Universitätsmedizin — Berlin, Germany
• Sussex Brighton R&D — Brighton, United Kingdom
• King's College Hospital NHS Foundation Trust — Brixton, United Kingdom
• Epsom and St Helier University Hospitals NHS Trust — Carshalton, United Kingdom
• Barts Health NHS Trust — London, United Kingdom
• St George's University Hospital NHS Trust Foundation — London, United Kingdom

Full record on ClinicalTrials.gov

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