Echocardiography: Value and Accuracy at REst and STress
Enrolling by invitation
Conditions studied: Coronary Artery Disease, Ischaemic Heart Disease, Angina Pectoris
In brief
EVAREST will identify and validate novel blood and imaging biomarkers of potential value for consistent and accurate interpretation of stress echocardiography. During phase one, blood samples will be collected to assess the impact of cardiac stress on levels of circulating biomarkers and examine whether the measurement of these biomarkers can provide additional prognostic information. Phases one, two and three will also determine whether novel imaging biomarkers can be identified in the echocardiograms that can be used for objective interpretation of the stress echocardiograms. EVAREST will recruit up to 8000 patients (First 500 during phase one, an additional 500 during phase two and an additional 7000 during phase three) from multiple hospitals across United Kingdom, who have been referred for a stress echocardiogram as part of their investigations into ischaemic heart disease. Phase four of the study will continue into a clinical study cohort phase to capture information from all patients referred for a stress echocardiogram in the UK, regardless of the reason for investigation.This registry phase will run for 2 years, recruiting up to 15000 participants.
Key facts
- Study ID
- NCT03674255
- Run by
- University of Oxford
- People needed
- 23000
- Starts
- 2015-03-01
- Expected to finish
- 2033-09-01
- Last updated by the study team
- 2026-04-29
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Patients must be undergoing a stress echocardiogram to investigate the presence of ischaemic heart disease (groups 1-3).
- Patients must be able to provide informed consent.
- Patients must be aged over 18 years of age.
You may not qualify if…
- Patients undergoing stress echocardiography to assess valvular function.
- Patients who are unwilling or unable to provide informed consent.
- Patients aged under 18 years of age.
Full record on ClinicalTrials.gov
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