Pharmacogenomic-Guided Antidepressant Drug Prescribing in Cancer Patients
Completed · Not applicable
Conditions studied: Depression, Anxiety, Generalized Anxiety Disorder, Depressive Disorder, Major Depressive Disorder, Cancer
In brief
This is a prospective, randomized clinical trial to investigate the clinical impact of a preemptive pharmacogenomics strategy to guide antidepressant therapy in cancer patients. Those enrolled onto the clinical trial will be randomized to either DNA-guided choice of therapy or clinical management alone. Scores on self-reported measures of depressive and anxiety symptoms along with quality of life will be compared between cohorts.
Key facts
- Study ID
- NCT03674138
- Run by
- H. Lee Moffitt Cancer Center and Research Institute
- People needed
- 99
- Starts
- 2018-09-12
- Expected to finish
- 2024-10-27
- Last updated by the study team
- 2026-02-06
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Patients with a cancer diagnosis
- Be 18 years of age or older
- Patients who rate depression or anxiety > 5 based on a 10 point scale
- Patients expected to live greater than 6 months
- Serum bilirubin and creatinine < 1.5x upper limit of normal
- AST and ALT < 3 times upper limit of normal
- Willing and able to provide written informed consent
- Able to complete self-assessment questionnaires
You may not qualify if…
- Patients not diagnosed with cancer
- Antidepressant prescribing performed by a non-Moffitt psychiatrist after enrollment onto the clinical trial
- Known Pregnancy
- History of liver or allogenic stem cell transplant
- Patients with a known cognitive impairment (e.g., delirium, dementia, etc.) or psychological impairment (e.g., schizophrenia, bipolar disease, etc.) other than depressive and anxiety symptoms.
Where it is running
- H. Lee Moffitt Cancer Center and Research Institute — Tampa, Florida, United States
Full record on ClinicalTrials.gov
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