Safety of Pregnancy in BRCA Mutated Breast Cancer Patients

Completed

Conditions studied: Breast Cancer

In brief

The present study aims at refining the understanding of the effect of pregnancy on breast cancer outcomes in the specific population of BRCA mutated patients with known history of breast cancer.

Key facts

Study ID

NCT03673306

Run by

Jules Bordet Institute

People needed

4732

Starts

2017-01-16

Expected to finish

2023-12-01

Last updated by the study team

2024-12-13

Who can join

Age: 18 and older, up to 40. Sex: female. Healthy volunteers: not accepted.

You may qualify if…

• Diagnosis of invasive breast cancer between January 2000 and December 2020;
• Breast cancer diagnosis at the age of ≤ 40 years;
• Known presence of germline BRCA mutation.

You may not qualify if…

• Known BRCA mutation with no diagnosis of invasive breast cancer;
• Diagnosis of ovarian cancer or other malignancies with no history of invasive breast cancer;
• Diagnosis of hereditary or familiar invasive breast cancer without BRCA mutation or with BRCA genes not tested;
• Diagnosis of invasive breast cancer with germline BRCA variants of unknown significance.

Where it is running

• Dana-Farber Cancer Institute — Boston, Massachusetts, United States
• Michigan State University — Lansing, Michigan, United States
• Mayo Clinic — Rochester, Minnesota, United States
• University of North Carolina - Lineberger Comprehensive Cancer Center — Chapel Hill, North Carolina, United States
• Cleveland Clinic Taussig Cancer Institute — Cleveland, Ohio, United States
• Lifespan Cancer Institute — Providence, Rhode Island, United States
• Hospital Aleman — Buenos Aires, Argentina
• Hospital Italiano de Buenos Aires — Buenos Aires, Argentina
• Instituto Alexander Fleming — Buenos Aires, Argentina
• kConFab, Follow-up Project — Melbourne, Victoria, Australia
• Peter MacCallum Cancer Centre — Melbourne, Victoria, Australia
• Medical University of Vienna — Vienna, Austria
• Cliniques Universitaires Saint-Luc UCL — Brussels, Belgium
• Institut Jules Bordet — Brussels, Belgium
• University Hospitals Leuven, KU Leuven — Leuven, Belgium
• Clinical Center University of Sarajevo — Sarajevo, Bosnia and Herzegovina
• Hospital Sírio-Libanês — Brasília, Brazil
• Cancer Institute ICESP — São Paulo, Brazil
• Mc Gill University — Montreal, Canada
• Bergonie Institute — Bordeaux, France
• Leon Berard Cancer Center — Lyon, France
• Hopital Saint Louis — Paris, France
• Institut Curie — Paris, France
• Centre Henri Becquerel — Rouen, France
• Yale University — New Haven, Connecticut, United States

Full record on ClinicalTrials.gov

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