Total Knee Arthroplasty Biomechanics

Completed · Not applicable

Conditions studied: Total Knee Arthroplasty (TKA)

In brief

In total knee arthroplasty (TKA), the relationship between implant design, soft tissue balance, neuromuscular contributions, and rehabilitation strategies on patient satisfaction and functional outcomes is highly complex and poorly understood. The investigators will prospectively study the effects of these factors using in vivo assessments preoperatively, and postoperatively. Computer simulation models will also be used to analyze lower extremity biomechanics.

Key facts

Study ID

NCT03671954

Run by

University of Florida

People needed

38

Starts

2019-05-01

Expected to finish

2023-11-16

Last updated by the study team

2023-11-30

Who can join

Age: 18 and older, up to 90. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Patients requiring unilateral TKA for knee osteoarthritis
• No osteoarthritis symptoms in contralateral knee
• Radiographic coronal deformity ≤ 15°
• Preoperative flexion ≥ 90°
• Receiving one of four implants used by UF Orthopaedic surgeons
• Able to walk for a short distance without the use of ambulatory aids
• Healthy Participants:
• Age 49-85 years
• Healthy with no signs or symptoms of lower limb arthritis or injury
• Able to walk for a short distance without the use of ambulatory aids

You may not qualify if…

• BMI > 40 kg/m2
• Presence of knee, hip, or ankle prosthesis for either limb
• Presence of hip prosthesis in surgical limb (TKA only subjects)
• History of lower limb or spinal surgery within the last year
• Presence of neurologic or orthopaedic disorders that could affect gait or balance
• Chronic opioid or illicit drug use
• Poorly controlled diabetes (HbA1C > 7 percent)
• Chronic pain syndrome
• Chronic back pain
• Presence of vestibular disorder
• Pregnancy

Where it is running

• UF & Shands Orthopaedics and Sports Medicine Institute — Gainesville, Florida, United States
• UF Health Florida Surgical Center — Gainesville, Florida, United States
• UF Health at the University of Florida — Gainesville, Florida, United States
• UF Health Cancer Hospital — Gainesville, Florida, United States

Full record on ClinicalTrials.gov

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