Multi-center Acute Severe Ulcerative Colitis Cohort Study (MASCC)

Completed

Conditions studied: Ulcerative Colitis

In brief

Ulcerative colitis (UC) is a chronic, progressive immunologically mediated disease affecting nearly 1 million Americans. Up to one third of patients with UC will require hospitalization for severe disease (termed 'acute severe colitis (ASUC)'), often within the first year after diagnosis. Investigators will develop a large multi-center cohort of patients with ASUC with homogeneously collected detailed longitudinal clinical and laboratory data.

Key facts

Study ID

NCT03669822

Run by

Johns Hopkins University

People needed

97

Starts

2018-11-10

Expected to finish

2024-12-31

Last updated by the study team

2025-01-24

Who can join

Age: 18 and older, up to 80. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Patients 18-80 years
• UC or IBD-unspecified (IBDU) diagnosed according to standard criteria
• Active disease defined as Simple Clinical Colitis Activity Index > 2 (day/night bowel frequency, urgency with defecation, blood in stool, general well-being, and extracolonic features)
• Admitted to the hospital
• Initiating intravenous corticosteroid therapy or medical rescue therapy

You may not qualify if…

• Patients with quiescent disease
• Inability to provide informed consent
• Prior colitis related surgery including J-pouch or stoma
• Non-IBD related hospital admission
• Women who are pregnant (from the specimen substudy only)
• Non - English speaking

Where it is running

• Joanna Melia — Baltimore, Maryland, United States

Full record on ClinicalTrials.gov

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