Dose-escalation and Dose-expansion Study of Safety of Azer-cel (PBCAR0191) in Participants With Relapsed/Refractory (r/r) Non-Hodgkin Lymphoma (NHL) and r/r B-cell Acute Lymphoblastic Leukemia (B-ALL)
Recruiting now · Phase 1
Conditions studied: Non-Hodgkin Lymphoma, B-cell Acute Lymphoblastic Leukemia, Chronic Lymphocytic Leukemia, Small Lymphocytic Lymphoma
In brief
This is a Phase 1/1b, nonrandomized, open-label, parallel assignment, dose-escalation, and dose-expansion study to evaluate the safety and clinical activity of azer-cel, an allogeneic anti-CD19 CAR T, in adults with r/r B ALL, r/r B-cell NHL and CLL/SLL.
Key facts
- Study ID
- NCT03666000
- Run by
- Imugene Limited
- People needed
- 135
- Starts
- 2019-03-11
- Expected to finish
- 2027-06-01
- Last updated by the study team
- 2026-02-02
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
Where it is running
- Barwon Health - Andrew Love Cancer Centre — Geelong, Victoria, Australia (enrolling)
- Columbia University Irving Medical Center/New York Presbyterian Hospital — New York, New York, United States (enrolling)
- Lifespan Cancer Institute at Rhode Island Hospital — Providence, Rhode Island, United States (enrolling)
- Baylor University Medical Center — Dallas, Texas, United States (enrolling)
- Medical College of Wisconsin — Milwaukee, Wisconsin, United States (enrolling)
- Royal Prince Alfred Hospital — Camperdown, New South Wales, Australia (enrolling)
- Liverpool Hospital — Liverpool, New South Wales, Australia (enrolling)
- Royal Adelaide Hospital — Adelaide, South Australia, Australia (enrolling)
- St Vincent's Hospital Melbourne — Fitzroy, Victoria, Australia (enrolling)
- H. Lee Moffitt Cancer Center — Tampa, Florida, United States (enrolling)
- Winship Cancer Institute Emory University — Atlanta, Georgia, United States (enrolling)
- Northside Hospital Cancer Institute — Atlanta, Georgia, United States (enrolling)
- University of Maryland — Baltimore, Maryland, United States (enrolling)
- Tufts Medical Center — Boston, Massachusetts, United States (enrolling)
- University of Minnesota — Minneapolis, Minnesota, United States (enrolling)
- City of Hope — Duarte, California, United States
- MD Anderson — Houston, Texas, United States
- Weill Cornell Medical College - NY Presbyterian Hospital — New York, New York, United States
- Banner MD Anderson Cancer Center — Gilbert, Arizona, United States
- Duke University — Durham, North Carolina, United States
- Ohio State University — Columbus, Ohio, United States
- Dana-Farber Cancer Institute — Boston, Massachusetts, United States
- Barbara Ann Karmanos Cancer Institute (Wayne State University) — Detroit, Michigan, United States
Full record on ClinicalTrials.gov
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