Effect of Different Skin Creams on TEWL

Completed · Phase 1

Conditions studied: Dermatitis, Atopic

In brief

Prospective, single center, clinical pilot study to test the hypothesis that lipid rich EpiCeram® is superior in improving skin barrier function compared to Aveeno Daily Moisturising Sheer Hydration Lotion®.

Key facts

Study ID

NCT03663673

Run by

Stanford University

People needed

17

Starts

2018-09-01

Expected to finish

2019-07-18

Last updated by the study team

2021-09-08

Who can join

Age: 0 and older, up to 40. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Parent guardian must be able to understand and provide informed consent per Institutional Review Board (IRB) guidelines and regulations.
• Male or female participants, between the ages of 0 to 40 years will be included
• Diagnosis of moderate to severe active AD (Scoring Atopic Dermatitis (SCORAD) score > 26) without a history or current manifestations of eczema herpeticum (EH)
• AD affecting at least 3 different skin areas (contralateral arms and one lower extremity)

You may not qualify if…

• Inability or unwillingness of a parent guardian to give written informed consent, or to comply with study protocol.
• Participants with skin disease other than AD that might compromise the stratum corneum barriers (e.g., bullous diseases, psoriasis, cutaneous T-cell lymphoma (also called Mycosis Fungoides or Sezary syndrome], dermatitis herpetiformis, Hailey-Hailey, or Darier's disease).
• Known or suspected immunosuppression
• Severe concomitant illness(es)
• History of serious life-threatening reaction to latex, tape, or adhesives
• Has received total body phototherapy (e.g., ultraviolet light B [UVB], psoralen ultraviolet light A [PUVA], tanning beds [>1 visit per week]) within 30 days of the Enrollment Visit
• Use of topical corticosteroids, topical immunomodulatory agents (such as calcineural inhibitors and crisaborole), or topical antibiotics on the upper or lower extremities within 7 days of the Enrollment Visit
• Has taken a bleach bath within 7 days of the Enrollment Visit
• Use of systemic antibiotics, antiparasitics, antivirals, or antifungals within 7 days of the Enrollment Visit.

Where it is running

• Sean N Parker Center For Allergy and Asthma Research — Mountain View, California, United States

Full record on ClinicalTrials.gov

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