The Impact of Statin Holiday in Dialysis Patients Over 70 Years Old on Mental Function, Physical Function and Frailty
Status unconfirmed · Phase 4
Conditions studied: ESRD, Cardiovascular Diseases
In brief
Patients who are on chronic dialysis and 70 and older are frequently on multiple medications including statins. However, the benefit of statins in dialysis patient population is uncertain. Several randomized trials showed no benefit of statins on mortality in dialysis patient population. Guidelines recommend not starting statins in patients on dialysis who are not already taking them. However, there are no guidelines on what to do in patients who are already taking statins. The investigators are doing a short pilot study to discontinue statin in our dialysis patient population and evaluating the effects on discontinuation of statins on quality of life, cognition, as physical strength.
Key facts
- Study ID
- NCT03663049
- Run by
- Loyola University
- People needed
- 30
- Starts
- 2018-08-17
- Expected to finish
- 2021-05-01
- Last updated by the study team
- 2019-04-23
Who can join
Age: 70 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Age 70 years and older,
- Receiving maintenance dialysis for at least 6 months,
- Must be on a statin medication,
- Receiving dialysis at the Loyola University Medical Center dialysis unit ,
- Can be on hemodialysis or peritoneal dialysis,
You may not qualify if…
- Age less than 70 years old
- Any recent hospital admission (within 2 weeks)
- Recent dialysis start (within 6 months)
- Any cancer diagnosis, with exception of innocuous skin cancers and previously treated cancers
- Any recent (< 1 year) solid organ transplant
- Active on kidney transplant wait list
- Recent acute coronary event (e.g. recent NSTEMI, stent, angioplasty, CABG) within 6 months
- Non-English speaking
- Diagnosis of dementia
- Patients who are unable to provide informed consent
Where it is running
- Loyola University Medical Center — Maywood, Illinois, United States (enrolling)
Full record on ClinicalTrials.gov
Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.