Speckle Tracking Echocardiography for the Prediction of Weaning Failure
Recruiting now · Not applicable
Conditions studied: Weaning Failure of Mechanical Ventilation
In brief
Deciding the optimal timing for extubation in patients who are mechanically ventilated can be challenging, and traditional weaning predictor tools are not accurate. Recent studies suggest that isolated sonographic assessment of the respiratory and cardiac function (ie diastolic function and filling pressure), in mechanically ventilated patients may assist in identifying patients at risk of weaning failure. Recently, the association of conventional echocardiography and lung ultrasound showed promising results for the prediction of post extubation distress. Speckle Tracking is an emerging tool in intensive care medicine that has never been investiguated for the prediction of weaning failure. It could early detects diastolic dysfunction and and elevated filling pressure. Of more, speckle tracking is known to be less operator dependant. The main objective of our study is to evaluate the diagnosis accuracy of speckle tracking echocardiography performed during a weaning trial to predict weaning failure. The secondary objectives are to assess the diagnosis accuracy of combined heart and lung ultrasound to predict weaning failure.
Key facts
- Study ID
- NCT03657524
- Run by
- Assistance Publique Hopitaux De Marseille
- People needed
- 110
- Starts
- 2019-05-20
- Expected to finish
- 2026-05-21
- Last updated by the study team
- 2026-02-12
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- Patients hospitalized in intensive care unit under mechanical fulfilling the criteria of ventilation weaning trial.
You may not qualify if…
- Less than 18 years old.
- Pregnancy
- Non sinusal cardiac rhythm
- Neuro Myopathy
- Tracheotomy
- Lack of echogenicity to perform at least a four chamber apical view
Where it is running
- Assistance Publique Hôpitaux de Marseille — Marseille, France (enrolling)
Full record on ClinicalTrials.gov
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