Brain Stimulation and Enhancing Cognition in Older Adults

Completed · Not applicable · Has a placebo group

Conditions studied: Cognitive Impairment, Mild, Depressive Symptoms, Anxiety

In brief

The aim of the current research is to evaluate the efficacy of a combination of Mindfulness-Based Stress Reduction (MBSR) and transcranial direct current stimulation (tDCS) to improve cognitive function in individuals with anxiety, depression and/or cognitive complaints.

Key facts

Study ID

NCT03653351

Run by

Washington University School of Medicine

People needed

26

Starts

2018-06-27

Expected to finish

2019-04-22

Last updated by the study team

2021-07-08

Who can join

Age: 60 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Community-dwelling men and women aged 60 or above.
• Current cognitive complaints per participant self-report, but with intact cognitive function as defined by a score of 0-9 on the Short Blessed Test (SBT) and a Montreal Cognitive Assessment (MoCA) score ≥25 per PI discretion.
• PROMIS depression scale score of greater or equal to 16 and/or PROMIS anxiety score greater or equal to 14.
• Ability to read and speak English fluently enough to complete all research assessments.
• Corrected visual ability to read newspaper headlines.
• Hearing capacity to respond to a raised conversational voice.
• Willingness and ability to provide informed consent.

You may not qualify if…

• The Mini-International Neuropsychiatric Interview (MINI) criteria for current or life-time bipolar disorder, schizophrenia, schizoaffective disorder.
• Untreated current post-traumatic stress disorder.
• A MoCA score <25 or SBT score >9, per PI discretion.
• Use of cognitive enhancers (namely, cholinesterase inhibitors such as donepezil; or memantine) within the past 6 weeks.
• MINI criteria for any substance abuse within 6 months that would affect their participation, per PI discretion.
• Unstable medical illness (e.g. uncontrolled diabetes mellitus or hypertension).
• Concurrent cognitive training, such as brain-training software, participation in psychotherapy or regular engagement in mindfulness practice and/or yoga.
• Taking anticonvulsant or antipsychotics that cannot be safely tapered and discontinued.

Where it is running

• Washington University in Saint Louis — St Louis, Missouri, United States
• Washington University School of Medicine — St Louis, Missouri, United States

Full record on ClinicalTrials.gov

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