Improving Infant Hydrocephalus Outcomes in Uganda

Running, not enrolling

Conditions studied: Hydrocephalus

In brief

Neonatal postinfectious hydrocephalus (PIH) is a major public health problem in East Africa.The standard treatment has long been placement of a ventriculoperitoneal shunt (VPS) but these devices require life-long maintenance and nearly all fail multiple times. Endoscopic Third Ventriculostomy (ETV) with Choroid Plexus Cauterization (ETV/CPC) is an alternate treatment to give patients a shunt-free life. In this study, the investigators aim to optimize the metrics of evaluation as quantitative prognostic indicators of treatment response and long term outcomes.

Key facts

Study ID

NCT03650101

Run by

Boston Children's Hospital

People needed

400

Starts

2021-05-05

Expected to finish

2027-12-01

Last updated by the study team

2026-03-18

Who can join

Age: 0 and older, up to 0. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Infants less than 180 days (six months) old
• Symptomatic hydrocephalus characterized by abnormal rate of head growth, full anterior fontanel, ventriculomegaly
• A parent or a guardian qualified by Ugandan law to give informed consent
• Patients from Eastern, Central and Northern districts of Uganda, and in geographic proximity to CURE hospital will be eligible

You may not qualify if…

• Age greater than six months
• No evidence of progressive hydrocephalus
• Patients outside of the districts specified in the inclusion criteria

Where it is running

• Penn State University — University Park, Pennsylvania, United States
• The Hospital for Sick Children — Toronto, Ontario, Canada
• Cure Children's Hospital of Uganda — Mbale, Uganda

Full record on ClinicalTrials.gov

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