Human Alcohol Seeking Despite Aversion

Stopped early · Not applicable

Conditions studied: Alcohol Abuse

In brief

Prolonged alcohol use results in drinking despite resultant problems and adverse consequences. The investigators propose to test a laboratory model of human seeking despite aversion to use as an early marker of disease onset, and as a tool for study of its neural functional substrates, and identification of effective treatments.

Key facts

Study ID

NCT03648840

Run by

Indiana University

People needed

84

Starts

2018-04-04

Expected to finish

2022-05-04

Last updated by the study team

2025-02-25

Who can join

Age: 21 and older, up to 55. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Healthy men and women age 21-55
• Range of lifetime alcohol drinking history from 25 kg to 500 kg, with preference for extremes, plus recent drinking at least 7 drinks/week (women) and 20 drinks/week (men)
• Able to understand and complete questionnaires and procedures in English
• Willing and able to tolerate iv placement
• Right-handed (for fMRI Arm only)

You may not qualify if…

• Pregnant or breast-feeding
• Seeking or in treatment for substance use disorder or under court ordered abstinence
• Medications, medical disorders or conditions that could affect study outcome or subject safety
• Positive urine drug screen for amphetamines/methamphetamines, barbiturates, benzodiazepines, cocaine, opiates, or phencyclidine
• Positive breath alcohol (BrAC) reading on arrival at any study visit
• Actively suicidal (within previous year)
• Left-handed or ambidextrous (for fMRI Arm only)

Where it is running

• University Hospital — Indianapolis, Indiana, United States

Full record on ClinicalTrials.gov

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