Postmenopausal Women and Their Endothelium

Completed · Phase 2 · Has a placebo group

Conditions studied: Postmenopausal Women

In brief

The purpose of this study is to test the effects of a one time dose and 7-days of inorganic nitrate (supplied in the form of beetroot juice) on blood vessel function and resting blood pressure in healthy, postmenopausal women. Participants will drink beetroot juice and a placebo juice on separate visits where blood pressure and blood vessel function will be measured.

Key facts

Study ID

NCT03644472

Run by

Penn State University

People needed

37

Starts

2018-11-07

Expected to finish

2023-02-20

Last updated by the study team

2023-02-27

Who can join

Age: any, up to 70. Sex: female. Healthy volunteers: accepted.

You may qualify if…

• Early post-menopausal women who are within 1-6 years following their final menstrual cycle
• Late post-menopausal women who are beyond 6 years following their final menstrual cycle

You may not qualify if…

• Individuals with any overt cardiovascular, metabolic, hematologic, pulmonary, renal, musculoskeletal, and/or neurological disease(s).
• Users of any tobacco and/or nicotine products (smokers, chewing tobacco, nicotine-containing patches/gum, smokeless cigarettes)
• Individuals with a BMI > 35
• Individuals with resting blood pressure > or = 130/80 mm Hg
• Individuals with high blood lipids (total cholesterol > or = 240 mg/dl, LDL > or = 160 mg/dl, triglycerides > or = 200 mg/dl).
• Postmenopausal women with hyperglycemia (fasting glucose > or = 110 mg/dl and HbA1c >6.0%).
• Individuals taking any of the following medications:
• blood pressure lowering medication (e.g., beta blockers, ACE inhibitors, angiotensin antagonists, calcium channel blockers, diuretics)
• lipid- lowering medication (e.g., statins)
• nitrates (e.g. nitroglycerin) for angina
• phosphodiesterase inhibitors (e.g., Viagra)
• anti-Inflammatory drugs
• Individuals taking hormone therapy

Where it is running

• Penn State University — University Park, Pennsylvania, United States

Full record on ClinicalTrials.gov

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