rTMS for Cognitive Rehabilitation After TBI
Completed · Not applicable · Has a placebo group
Conditions studied: Cognitive Impairment, Traumatic Brain Injury
In brief
A novel and promising therapy for cognitive dysfunction is non-invasive brain stimulation, of which transcranial magnetic stimulation (TMS) is a form. TMS is currently FDA-approved for use in depression and migraine. It is under investigation for use in a number of other neurologic and psychiatric disorders. In addition to its potential to improve affective symptoms, recent research has suggested that TMS targeted to select cortical regions can also improve cognition. In trials of TMS therapy for psychiatric disorders, several studies have shown benefits for cognitive function alongside symptom amelioration. In healthy persons, a course of stimulation of the parietal area improved objective measures of learning and memory. Among persons with TBI, there have been case reports supporting improvement in cognitive function and postconcussive symptoms; however, there have not yet been any controlled studies of TMS for TBI-related cognitive dysfunction.
Key facts
- Study ID
- NCT03642158
- Run by
- Hunter Holmes Mcguire Veteran Affairs Medical Center
- People needed
- 34
- Starts
- 2017-12-01
- Expected to finish
- 2020-11-30
- Last updated by the study team
- 2021-02-09
Who can join
Age: 18 and older, up to 65. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- one or more mild to moderate TBIs*;
- at least one year but no more than 20 years from worst injury;
- ability to complete cognitive and neurophysiological testing;
- available for duration of study;
- between 18 and 65 years of age;
- mild or greater cognitive symptoms on the TBI-QOL Cognition General Concerns scale
You may not qualify if…
- severe or penetrating TBI;
- history of psychotic or manic illness;
- history of intracranial surgery;
- history of skull fracture;
- history of seizures in candidate or candidate's family
- ferrous metallic implants or implantable medical device;
- medications that are known to reduce seizure threshold;
- pregnancy.
- history of multiple sclerosis, stroke, brain tumor, epilepsy
Where it is running
- Hunter Holmes McGuire Veterans Affairs Medical Center — Richmond, Virginia, United States
Full record on ClinicalTrials.gov
Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.