Evaluation of the Safety and Efficacy of TLD in Patients with COPD

Running, not enrolling · Not applicable · Has a placebo group

Conditions studied: COPD

In brief

The purpose of this study is to confirm the safety and efficacy of the Nuvaira Lung Denervation System (Nuvaira System) in the treatment of COPD.

Key facts

Study ID: NCT03639051
Run by: Nuvaira, Inc.
People needed: 464
Starts: 2019-05-23
Expected to finish: 2028-09-01
Last updated by the study team: 2024-11-14

Who can join

Age: 40 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

Subject ≥40 years of age at the time of consent;
Women of child bearing potential must not be pregnant, evidenced by a negative pregnancy test (blood or urine) pre-treatment, or lactating and agree not to become pregnant for the duration of the study;
Smoking history of at least 10 pack years;
Not smoking or using any other inhaled substance (e.g., cigarettes, vaping, cannabis, pipes) for a minimum of 2 months prior to consent and agrees to not start for the duration of the study;
Subject has received a flu vaccination within the 12 months prior to the procedure or agrees to obtain vaccination once it becomes available and agrees to annual vaccinations for the duration of the study;
Resting SpO2 ≥89% on room air at the time of screening;
CAT score ≥10 at the time of screening;
Diagnosis of COPD with 25%≤ FEV1 ≤80% of predicted, PaCO2 ˂ 50 (if FEV1 ˂30%) and FEV1/FVC <70% (post-bronchodilator);
Documented history of ≥ 2 moderate COPD exacerbations or ≥ 1 severe COPD exacerbation leading to hospitalization in the 12 months prior to consent with at least one exacerbation occurring while the subject was on optimal medical care (taking LAMA and a LABA, or scheduled SABA or SAMA instead of either a LAMA or LABA, not both, as regular respiratory maintenance medication);
Subject is on optimal medical care at the time of consent;
If subject has participated in a formal pulmonary rehabilitation program recently, program completion must have occurred ≥3 months prior to consent; if in a maintenance program, subject agrees to continue their current program through their 12-month follow-up visit;
Subject is a candidate for bronchoscopy in the opinion of the physician or per hospital guidelines and is able to discontinue blood thinning medication peri-procedurally;
The subject is able and agrees to complete all protocol required baseline and follow-up tests and assessments including taking certain medications (e.g., azithromycin, prednisolone/prednisone);
Subject has provided written informed consent using a form that has been reviewed and approved by the Institutional Review Board (IRB)/Ethics Committee (EC).

You may not qualify if…

Body Mass Index <18 or >35;
Subject has an implantable electronic device and has not received appropriate medical clearance;
Uncontrolled diabetes in the opinion of the investigator;
Malignancy treated with radiation or chemotherapy within 1 year of consent;
Asthma as defined by the current Global Initiative for Asthma (GINA) guidelines;
Subject diagnosed with a dominant non-COPD lung disease or condition affecting the lungs, which is the main driver of the subjects clinical symptoms (e.g., cystic fibrosis, paradoxical vocal cord motion, eosinophilic granulomatosis with polyangiitis (EGPA), allergic bronchopulmonary aspergillosis, interstitial lung disease or active tuberculosis) or has a documented medical history of pneumothorax within 1 year of consent;
Clinically relevant bronchiectasis, defined as severe single lobe or multilobar broncial wall thickening associated with airway dilation on CT scan leading to cough and tenacious sputum on most days;
Pre-existing diagnosis of pulmonary hypertension, clinical evidence of pulmonary hypertension (e.g., cardiovascular function impairment including peripheral edema) and mPAP ≥25 mmHg at rest by right heart catheterization (or estimated right ventricular systolic pressure >50 mmHg by echocardiogram if no previous right heart catheterization);
Myocardial infarction within last 6 months, EKG with evidence of life threatening arrhythmias or acute ischemia, pre-existing documented evidence of an LVEF <40%, stage C or D (ACC/AHA) or Class III or IV (NYHA) congestive heart failure, or any other past or present cardiac findings that make the subject an unacceptable candidate for a bronchoscopic procedure utilizing general anesthesia;
Surgical procedure(s) on the stomach, esophagus or pancreas performed ≤2 years of consent or ongoing related symptoms within the past year;
Symptomatic gastric motility disorder(s) (e.g., gastroparesis) as evidenced by a GCSI score ≥18.0, severe uncontrolled GERD (e.g., refractory heartburn, endoscopic esophagitis) or severe dysphagia (e.g., esophageal stricture, achalasia, esophageal spasm);
Any disease or condition that might interfere with completion of a procedure or this study (e.g., structural esophageal disorder, life expectancy <3 years);
Prior lung or chest procedure (e.g., lung transplant, LVRS, BLVR, lung implant, metal stent, valves, median sternotomy, bullectomy, lobectomy, segmentectomy or other interventional lung or chest procedure) performed ≤1 year of consent; NOTE: Any metal in the chest must be ≥5 cm away from the anticipated treatment location(s). Subjects with explanted lung valve(s) allowed if explant occurred ≥3 months prior to treatment.
Daily use of >10 mg of prednisone or its equivalent at the time of consent;
Chronic use of >40 mg MEDD opioid only medication per day;
Known contraindication or allergy to medications required for bronchoscopy or general anesthesia (e.g., lidocaine, atropine, propofol, sevoflurane) that cannot be medically controlled;
Baseline chest CT scan reveals bronchi anatomy cannot be fully treated with available catheter sizes, presence of severe emphysema >50%, lobar attenuation area or severe bullous disease (>1/3 hemithorax) (as determined by the CT core lab using a single density mask threshold of -950 HU) or discovery of a mass that requires treatment;
Subject is currently enrolled in another interventional clinical trial that has not completed follow-up.

Where it is running

University of Alabama at Birmingham (UAB) Lung Health Center — Birmingham, Alabama, United States
HonorHealth — Phoenix, Arizona, United States
UC Davis — Sacramento, California, United States
Harbor UCLA — Torrance, California, United States
Ascension St. Vincent's — Jacksonville, Florida, United States
University of Chicago — Chicago, Illinois, United States
Suburban Lung Associates — Elk Grove Village, Illinois, United States
University of Louisville — Louisville, Kentucky, United States
Lahey Hospital & Medical Center — Burlington, Massachusetts, United States
University of Michigan — Ann Arbor, Michigan, United States
Spectrum Health Medical Group — Grand Rapids, Michigan, United States
Washington University — St Louis, Missouri, United States
Duke University — Durham, North Carolina, United States
First Health of the Carolinas — Pinehurst, North Carolina, United States
Ohio State University Wexner Medical Center — Columbus, Ohio, United States
Temple Lung Center — Philadelphia, Pennsylvania, United States
University of Pittsburgh Medical Center (UPMC) — Pittsburgh, Pennsylvania, United States
Medical University of South Carolina (MUSC) — Charleston, South Carolina, United States
St. Davids HealthCare — Georgetown, Texas, United States
Houston Methodist Hospital — Houston, Texas, United States
Krankenhaus Nord - Klinik Floridsdorf — Vienna, Austria
CHU de Grenoble — Grenoble, Cedex 9, France
Hopital Larrey — Toulouse, Cedex 9, France
Hopital de la Cavale Blanche — Brest, France
Arnaud de Villeneuve Hospital — Montpellier, France

Full record on ClinicalTrials.gov

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