Long- Term Transcranial Direct Current Stimulation in Parkinson's Disease

Status unconfirmed · Phase 2 · Has a placebo group

Conditions studied: Parkinson Disease

In brief

The goal of the proposed research is to determine the influence of transcranial direct current stimulation (tDCS) on long-term motor learning, transfer of motor learning, and cortical function in Parkinson's disease (PD). The project comprises a 2 week training study that will involve tDCS applied during two practice motor tasks with behavioral, clinical, and physiological evaluations at baseline as well as 1, 14 and 28 days following the 2 week training and stimulation period. The findings of the proposed studies should have significant clinical significance and applications to comprehensive intervention therapy development in the treatment of PD.

Key facts

Study ID

NCT03638531

Run by

University of Nevada, Las Vegas

People needed

40

Starts

2018-07-30

Expected to finish

2020-12-31

Last updated by the study team

2018-10-19

Who can join

Age: 60 and older, up to 75. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Able to provide informed consent.
• A clinical diagnosis of idiopathic PD.
• A stable and optimal medical regimen of anti-parkinsonian drug therapy for the duration of the study.
• Modified Hoehn and Yahr stage between 1.0 and 3.0 in the OFF state.
• Right-hand dominant and primarily right-side affected to prevent confounds due to handedness and affected side.

You may not qualify if…

• An uncontrolled medical condition (i.e. hypertension, diabetes, etc).
• Evidence of secondary or atypical parkinsonism as suggested by:
• History of CVA's, exposure to toxins, neuroleptics or encephalitis.
• Neurologic signs of upper motor neuron or cerebellar involvement, supranuclear gaze palsy or significant orthostatic hypertension.
• Metal in the skull or the eye, such as a cardiac pacemaker, brain stimulator, shrapnel, surgical metal, clips in the brain, cochlear implants, and metal fragments in the eye, as these may make TMS and tDCS unsafe.
• An uncertainty about the presence of metal objects in a subject's body exists.
• Hearing loss, have had a brain tumor, a stroke, head trauma, epilepsy or a history of seizures, have another neurological disorder other than a movement disorder, or have a head injury where they passed out for more than a few seconds.
• Pregnant or thought to be pregnant.
• Irrepressible dyskinesia or tremor to prevent the confound of excessive EMG during TMS testing at rest.
• Any other neurological disorders.
• Meeting of any of the TMS exclusion criteria given in international guidelines.

Where it is running

• Bigelow Health Sciences — Las Vegas, Nevada, United States

Full record on ClinicalTrials.gov

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