Physical Activity on Neurophysiologic Gene Expression Profiles of Chronic Low Back Pain
Completed · Not applicable
Conditions studied: Chronic Low Back Pain, Self-Management
In brief
This pilot project will provide an understanding of the contextual variables responsible for chronic low back pain. These variables include, genetic variation, pain sensitivity, reactivity, pain catastrophizing, perceived stress and kinesiphobia. The purpose is to understand the initial efficacy of self-management (SM) strategies on each of these contextual variables, in an effort to inform a personalized approach to managing chronic low back pain and its effect on improved health outcomes.
Key facts
- Study ID
- NCT03637998
- Run by
- University of Connecticut
- People needed
- 40
- Starts
- 2018-09-21
- Expected to finish
- 2021-12-31
- Last updated by the study team
- 2023-11-28
Who can join
Age: 18 and older, up to 60. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- be 18-60 years of age;
- have nonspecific cLBP (≥4 on the numeric rating scale; NRS) present for at least 3 out of the last 6 months and ≥ half the days in the past 6 months;
- comprehend English (due to lack of reliability and validity of study instruments and the intervention in non-English populations).
- Have daily access to a computer, tablet or smartphone with access to internet
- Have less than 150 minutes of moderate physical activity a week
- Be willing to wear activity tracker for 12 weeks
You may not qualify if…
- Chronic pain at another site or associated with a painful condition (eg., fibromyalgia, neuropathy, rheumatoid arthritis)
- history of comorbidities that affect sensorimotor function (eg., multiple sclerosis, cancer, spinal cord injury, diabetes)
- previous spinal surgery within last 1 year
- presence of neurological deficits such as weakness in the lower extremities (motor strength 4/5 of quads, glutes, hamstrings, EHL)
- bowel or bladder dysfunction such as difficulty voiding or incontinence
- sciatica or (+) leg raise
- positive Romberg test
- being pregnant or within 3 months postpartum
- history of psychological disorders (major depression, bipolar disorder, schizophrenia)
- identification of any "red flag" condition in the volunteer's past medical history that suggests specific LBP as determined by Dr. Kim such as conditions or medications that can affect pain sensitivity
- injury to non-dominant hand or presence of open skin lesions, disturbed sensation, carpal tunnel or rash
Where it is running
- University of Connecticut — Storrs, Connecticut, United States
Full record on ClinicalTrials.gov
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