The Human Microbiome and IVF Outcomes
Completed
Conditions studied: Infertility
In brief
Patients and partners undergoing an autologous IVF cycle will be recruited to participate in this prospective observational study investigating the microbiome and its association with IVF pregnancy outcomes. During the the controlled ovarian hyperstimulation cycle as well as the frozen embryo transfer cycle, a number of specimens will be collected for next generation sequencing of 16S rRNA to evaluate the microbiome profile of the reproductive and gastrointestinal tracts. Data on pregnancy outcomes will be collected prospectively and evaluated to identify associations with the microbiome.
Key facts
- Study ID
- NCT03637777
- Run by
- Reproductive Medicine Associates of New Jersey
- People needed
- 332
- Starts
- 2018-08-13
- Expected to finish
- 2022-12-15
- Last updated by the study team
- 2023-05-03
Who can join
Age: 18 and older, up to 45. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Patients initiating an autologous IVF cycle
- Patient age 18-45; partner age 18-60
- Partner planning to provide fresh semen sample on day of oocyte retrieval
- Patients planning to undergo preimplantation genetic screening (PGS) of embryos with single embryo transfer (SET)
You may not qualify if…
- > 1 prior failed IVF cycle
- Third party reproduction
- Planning to bank embryos
- Partner using cryo sperm or surgical sperm on day of retrieval
- Male or female partner antibiotic use within 1 month of IVF cycle start
- Mullerian anomalies, excluding arcuate uterus
- Submucosal fibroids
- History of uterine surgery, excluding polypectomy, D\&C, and Cesarean section
- Communicating hydrosalpinx without plans for surgical correction prior to embryo transfer
Where it is running
- IVI RMA New Jersey — Basking Ridge, New Jersey, United States
Full record on ClinicalTrials.gov
Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.