Predicting Ipsilesional Motor Deficits in Stroke With Dynamic Dominance Model

Completed · Not applicable · Has a placebo group

Conditions studied: Stroke

In brief

This study will test the hypothesis that the combination of low-moderate to severe motor deficits in the paretic arm and persistent motor deficits in the less-impaired arm limits functional independence in chronic stroke survivors. We, therefore, predict that intense remediation, focused on improving the speed, coordination, and accuracy of the less-impaired arm should improve functional independence.

Key facts

Study ID

NCT03634397

Run by

Robert L. Sainburg

People needed

58

Starts

2019-02-02

Expected to finish

2024-08-05

Last updated by the study team

2025-09-12

Who can join

Age: 18 and older, up to 85. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• neuroradiological confirmation of unilateral brain damage with residual contralesional upper-extremity weakness
• deficits in ipsilesional arm performance assessed by the JTHFT
• 6+ months post stroke
• Demonstrates cognitive abilities

You may not qualify if…

• a history of:
• neurological disease other than stroke (e.g., head trauma)
• a major psychiatric diagnosis (e.g., schizophrenia, major affective disorder),
• hospital admission for substance abuse
• peripheral disorders affecting sensation or movement of the upper extremities, including pain or arthritis
• currently taking prescription drugs with known sedative properties that are interfering with sensory-motor function
• significant joint pain that is activity limiting
• bilateral stroke

Where it is running

• University of Southern California — Los Angeles, California, United States
• Penn State College of Medicine — Hershey, Pennsylvania, United States

Full record on ClinicalTrials.gov

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