Safety, Tolerability, Immunogenicity, and Antitumor Activity of GEN-009 Adjuvanted Vaccine
Completed · Phase 1/Phase 2
Conditions studied: Cutaneous Melanoma, Non-small Cell Lung Cancer, Squamous Cell Carcinoma of the Head and Neck, Urothelial Carcinoma, Renal Cell Carcinoma
In brief
In this study, Genocea is evaluating an investigational, personalized adjuvanted vaccine, GEN-009, that is being developed for the treatment of patients with solid tumors. A proprietary tool developed by Genocea, called ATLAS™ (Antigen Lead Acquisition System) will be used to identify neoantigens in each patient's tumor that are recognized by their CD4 and/or CD8 T cells. ATLAS-identified neoantigens will then be incorporated into a patient's personalized vaccine in the form of synthetic long peptides (SLPs).
Key facts
- Study ID
- NCT03633110
- Run by
- Genocea Biosciences, Inc.
- People needed
- 24
- Starts
- 2018-08-29
- Expected to finish
- 2022-02-28
- Last updated by the study team
- 2022-04-19
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
Where it is running
- UC San Diego Moores Cancer Center — La Jolla, California, United States
- John Wayne Cancer Institute - Providence Saint John's Health Center — Santa Monica, California, United States
- University of Colorado, Anschutz Cancer Pavilion — Aurora, Colorado, United States
- Dana-Farber Cancer Institute — Boston, Massachusetts, United States
- Karmanos Cancer Institute — Detroit, Michigan, United States
- University of Nebraska Medical Center — Omaha, Nebraska, United States
- Columbia University Medical Center - Herbert Irving Pavilion — New York, New York, United States
- Hospital of the University of Pennsylvania — Philadelphia, Pennsylvania, United States
- The Sarah Cannon Research Institute — Nashville, Tennessee, United States
- The University of Texas MD Anderson Cancer Center — Houston, Texas, United States
- University of Wisconsin Carbone Cancer Center — Madison, Wisconsin, United States
Full record on ClinicalTrials.gov
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