Slowly Digestible Carbohydrates and the Ileal Brake

Completed · Not applicable

Conditions studied: Obesity, Diabetes Mellitus, Type 2, Appetitive Behavior

In brief

The ileal brake is a feedback mechanism controlling stomach-mediated transit of a meal, for which gastric emptying can be used as an indicator. Previously, slowly digestible carbohydrates (SDCs) were shown to activate the ileal brake in a rat model; the current research aimed to determine the effect of common SDCs in humans.

Key facts

Study ID

NCT03630445

Run by

Purdue University

People needed

20

Starts

2015-06-02

Expected to finish

2015-07-31

Last updated by the study team

2021-03-10

Who can join

Age: 18 and older, up to 50. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• BMI 18.5 - 25 kg/m2
• Stable weight for the past 3 months (i.e. +/- 2..5 kg)
• Regular eating patterns, including breakfast consumption

You may not qualify if…

• Gastrointestinal disease
• Smokers
• Peri- or post-menopausal women
• Celiac disease (yogurts may contain ingredients with wheat origin)
• Allergies, including dairy, lactose, and gluten
• Pregnant and lactating women
• Following a weight reduction program or having followed one during the last 3 months
• Acute or chronic disease
• Alcohol consumption > 30 units/week
• Hypertension
• Diabetes
• Previous bariatric surgery

Where it is running

• Purdue University — West Lafayette, Indiana, United States

Full record on ClinicalTrials.gov

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