Comparison of 24-hours Versus 72-hours of Octreotide Infusion in Preventing Early Rebleed From Esophageal Varices

Stopped early · Phase 4

Conditions studied: Esophageal Varices, Liver Cirrhoses, Bleeding Esophageal Varices, Upper Gastrointestinal Bleeding

In brief

This study evaluates the safety and efficacy of 24-hour vs 72-hour octreotide infusion after variceal banding in cirrhotic patients with bleeding esophageal varices.

Key facts

Study ID

NCT03624517

Run by

Medical University of South Carolina

People needed

34

Starts

2018-09-19

Expected to finish

2024-12-01

Last updated by the study team

2025-11-20

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Adult males and females who are 18 years of age or older.
• Evidence or suspicion of upper gastrointestinal bleed (GIB)
• Patient with known or suspected cirrhosis
• Upper GIB secondary to bleeding esophageal varices as show by esophageal endoscopy, requiring endoscopic band ligation (EBL) at presentation
• Willing and able to provide informed consent for study, or have a Legally authorized representative (LAR) provide consent if the patient is unable to do so

You may not qualify if…

• Known upper gastrointestinal malignancy
• Bleeding from gastric varices, with or without esophageal varices
• Use of any other endoscopic method to stop GI bleeding beyond endoscopic band ligation
• Variceal bleeding in the last 90 days
• History of transjugular, intrahepatic, portosystemic shunt (TIPS) or vascular decompression surgery
• Pregnant females
• Incarcerated individuals
• Myocardial infarct, cerebrovascular accident, sepsis, respiratory failure, or severe intercurrent illness within the previous 6 weeks
• Non-cirrhotic portal hypertension causing esophageal varices
• Known or suspected allergy to octreotide

Where it is running

• University of Florida Health — Jacksonville, Florida, United States
• University of Illinois at Chicago — Chicago, Illinois, United States
• The Ohio state University — Columbus, Ohio, United States
• Oregon Health & Science University — Portland, Oregon, United States
• Medical University of South Carolina — Charleston, South Carolina, United States
• The University of Texas at Austin — Austin, Texas, United States
• Texas Tech University Health Sciences Center — El Paso, Texas, United States
• Brooke Army Medical Center — Houston, Texas, United States

Full record on ClinicalTrials.gov

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