Safety and Tolerability of Conversion From Oral, Injectable, or Infusion Disease Modifying Therapies to Dose-titrated Oral Siponimod (Mayzent) in Advancing RMS Patients

Completed · Phase 3

Conditions studied: Multiple Sclerosis, Relapsing Multiple Sclerosis, Advancing Multiple Sclerosis

In brief

To assess safety and tolerability of patients converting from approved Relapsing Multiple Sclerosis (RMS) Disease Modifying Therapies (DMTs) to siponimod.

Key facts

Study ID

NCT03623243

Run by

Novartis Pharmaceuticals

People needed

185

Starts

2019-02-14

Expected to finish

2022-07-06

Last updated by the study team

2024-06-20

Who can join

Age: 18 and older, up to 65. Sex: any. Healthy volunteers: not accepted.

Where it is running

• Novartis Investigative Site — Cullman, Alabama, United States
• Alabama Neurology Associates — Homewood, Alabama, United States
• Novartis Investigative Site — Tucson, Arizona, United States
• Novartis Investigative Site — Fresno, California, United States
• Novartis Investigative Site — Fullerton, California, United States
• Novartis Investigative Site — Irvine, California, United States
• Novartis Investigative Site — Colorado Springs, Colorado, United States
• Novartis Investigative Site — Denver, Colorado, United States
• Novartis Investigative Site — Fort Collins, Colorado, United States
• Novartis Investigative Site — Boca Raton, Florida, United States
• Novartis Investigative Site — Bradenton, Florida, United States
• MS & Neuromuscular Center of Excellence — Clearwater, Florida, United States
• Novartis Investigative Site — Maitland, Florida, United States
• Novartis Investigative Site — Miami, Florida, United States
• Novartis Investigative Site — Ocala, Florida, United States
• Novartis Investigative Site — Oldsmar, Florida, United States
• Novartis Investigative Site — Orlando, Florida, United States
• Novartis Investigative Site — Ormond Beach, Florida, United States
• Novartis Investigative Site — Sarasota, Florida, United States
• Novartis Investigative Site — Sunrise, Florida, United States
• Novartis Investigative Site — Tampa, Florida, United States
• Novartis Investigative Site — Vero Beach, Florida, United States
• Novartis Investigative Site — Flossmoor, Illinois, United States
• Novartis Investigative Site — Indianapolis, Indiana, United States
• Novartis Investigative Site — Birmingham, Alabama, United States

Full record on ClinicalTrials.gov

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