Placebo-Controlled Study of Brazikumab in Participants With Moderately to Severely Active Ulcerative Colitis

Stopped early · Phase 2 · Has a placebo group

Conditions studied: Ulcerative Colitis, IBD

In brief

The present study (D5272C00001/Legacy #3151-201-008) aims to evaluate the efficacy and safety of brazikumab in patients with moderately to severely active UC and will include assessments of clinical responses as demonstrated by improvement of symptoms and of colonic mucosal appearance as observed on endoscopy

Key facts

Study ID: NCT03616821
Run by: AstraZeneca
People needed: 242
Starts: 2018-08-07
Expected to finish: 2023-10-23
Last updated by the study team: 2026-06-23

Who can join

Age: 18 and older, up to 80. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

Ability to provide informed consent
Aged 18 to 80 years of age
Diagnosis of UC with an onset of symptoms for a minimum of 3 months prior to Screening
Evidence of UC extending proximal to the rectum (≥ 15 cm of involved colon)
Moderately to severely active UC as defined by:
Average daily mMS Stool Frequency subscore ≥ 1 AND Average daily mMS Rectal Bleeding subscore ≥ 1
Modified Mayo endoscopic subscore of ≥ 2 based on a full colonoscopy within 14 days prior to randomization.
Participant had an inadequate response or intolerance to intervention with conventional treatment or prior biological treatment or demonstrated CS dependence for the treatment of UC. For participants who have previously used biological treatment, a participant may have failed up to 3 biologics that include up to 2 different mechanisms of action.
Participants taking 5-aminosalicylates, oral prednisone (or equivalent), oral budesonide, or immunomodulators must be at a stable dose or discontinued. Topical (rectal) aminosalicylic acid or topical (rectal) steroids should be discontinued.
Female participants of childbearing potential must have a negative urine pregnancy test prior to administration of study intervention and must agree to use a highly effective method of birth control throughout the study and for at least 18 weeks after the last dose of study intervention.
Women not of childbearing potential are defined as women who are either permanently sterilized (hysterectomy, bilateral oophorectomy, or bilateral salpingectomy), or who are postmenopausal.
Non sterilized males who are sexually active with a female partner of childbearing potential should use condoms during treatment and until the end of relevant systemic exposure in the male participant, plus a further 18 weeks.
No known history of active TB or latent TB without completion of appropriate intervention and negative QFT-TB during Screening.
Complete inclusion criteria are in the Clinical Study Protocol

You may not qualify if…

Participant has UC limited to the rectum (ie, not beyond 15 cm of the anal verge).
Current diagnosis of fulminant colitis, a diagnosis of CD or indeterminate colitis, presence or history of a fistula consistent with CD, primary sclerosing cholangitis, celiac disease, or untreated bile acid malabsorption. Participants with a history of toxic megacolon within 12 months of screening are excluded.
History of subtotal colectomy with ileorectostomy or colectomy with ileoanal pouch, Koch pouch, ileostomy, or other prior colonic resection, or need for surgical intervention for control of UC anticipated within 6 months.
Participant has received the following treatment:
Infliximab: within 8 weeks prior to randomization.
Adalimumab, certolizumab pegol, or golimumab: within 8 weeks prior to randomization.
Vedolizumab or ustekinumab within 12 weeks of randomization.
Other prohibited medication, biologic or small molecule treatment within 5 half-lives prior to randomization.
Fecal microbiota transplantation: within 8 weeks prior to randomization.
Criterion deleted as part of Amendment 5 v6.0
Except for ustekinumab, prior exposure to any biologic agent targeting IL-12 or IL-23.
Known history of allergy to the study intervention formulation or any of its excipients or components of the delivery device, or to any other biologic therapy.
Participant received cyclosporine, mycophenolate mofetil, sirolimus (rapamycin), thalidomide, tacrolimus (FK-506), or tofacitinib within 2 weeks prior to Screening.
Participants who received IV or intramuscular steroids within 2 weeks prior to Screening.
Participant is currently enrolled in another investigational device or drug study, or is within 35 days or 5 half-lives, whichever is longer, since ending another investigational device or drug study(s), or receiving other investigational agent(s).
Participant received a transfusion of blood, plasma, or platelets within 30 days prior to Screening.
Participant received a Bacille Calmette-Guérin vaccination within 12 months of randomization or any other live vaccine less than 4 weeks prior to randomization.
Participant has any of the following criteria related to infections:
Evidence of a recent systemic fungal infection, requiring inpatient hospitalization, and/or antifungal treatment.
Any infection requiring hospitalization or treatment with IV anti-infectives within 4 weeks of Screening.
Cytomegalovirus or Epstein-Barr virus infection that has not resolved within 8 weeks prior to Screening.
Clinically significant chronic infection that has not resolved within 8 weeks of Screening.
Nonserious infection requiring oral anti-infectives within 2 weeks prior to randomization must be further discussed with study medical monitor.
Clinical evidence of or suspected to have an abscess during Screening.
Any underlying condition that predisposes the participant to infections.

Where it is running

Research Site — Tucson, Arizona, United States
Research Site — Little Rock, Arkansas, United States
Research Site — Chula Vista, California, United States
Research Site — Lancaster, California, United States
Research Site — Lincoln, California, United States
Research Site — Mission Hills, California, United States
Research Site — Poway, California, United States
Research Site — Colorado Springs, Colorado, United States
Research Site — Clearwater, Florida, United States
Research Site — Inverness, Florida, United States
Research Site — Kissimmee, Florida, United States
Research Site — Lakeland, Florida, United States
Research Site — Miami, Florida, United States
Research Site — Miami, Florida, United States
Research Site — Miami Lakes, Florida, United States
Research Site — Naples, Florida, United States
Research Site — New Port Richey, Florida, United States
Research Site — Tampa, Florida, United States
Research Site — Tampa, Florida, United States
Research Site — Atlanta, Georgia, United States
Research Site — Gurnee, Illinois, United States
Research Site — Oak Lawn, Illinois, United States
Research Site — Brownsburg, Indiana, United States
Research Site — Evansville, Indiana, United States
Research Site — Phoenix, Arizona, United States

Full record on ClinicalTrials.gov

Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.