A Study of Pregnant and Postpartum Women With and Without Mood Disorders
Completed
Conditions studied: Bipolar Disorder, Major Depressive Disorder, Postpartum Depression, Postpartum Psychosis
In brief
This study is looking at genetic, biological, and environmental causes and how all three may work together to cause postpartum mood episodes. Participants will have psychiatric histories taken and will be monitored throughout pregnancy and during the postpartum period for the development of depressive or other mood episodes. Biological measures, including hormone levels, immunological measures, and growth factors will be collected. Environmental factors such as sleep deprivation and stress will also be measured. These factors will be considered in the setting of genetic and epigenetic data with the hope that investigators will ultimately be able to predict the onset of postpartum mood episodes in this vulnerable population.
Key facts
- Study ID
- NCT03615794
- Run by
- Johns Hopkins University
- People needed
- 300
- Starts
- 2017-10-01
- Expected to finish
- 2024-05-06
- Last updated by the study team
- 2025-12-30
Who can join
Age: 18 and older, up to 50. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- Pregnant women with singleton pregnancies
- With or without a history of a mood disorder (MDD, Bipolar I, Bipolar II or Bipolar NOS)
You may not qualify if…
- Current active suicidal ideation
- Medical or psychiatric instability
- Active substance abuse or dependence during the last 90 days
- Presence or development of significant pregnancy conditions that may have independent effects on outcomes
Where it is running
- 550 North Broadway — Baltimore, Maryland, United States
- University of Virginia — Charlottesville, Virginia, United States
Full record on ClinicalTrials.gov
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