APOL1 Long-term Kidney Transplantation Outcomes Network (APOLLO)
Running, not enrolling
Conditions studied: Kidney Diseases, Kidney Failure, Kidney Disease, Chronic
In brief
The APOLLO study is being done in an attempt to improve outcomes after kidney transplantation and to improve the safety of living kidney donation based upon variation in the apolipoprotein L1 gene (APOL1). Genes control what is inherited from a family, such as eye color or blood type. Variation in APOL1 can cause kidney disease. African Americans, Afro-Caribbeans, Hispanic Blacks, and Africans are more likely to have the APOL1 gene variants that cause kidney disease. APOLLO will test DNA from kidney donors and recipients of kidney transplants for APOL1 to determine effects on kidney transplant-related outcomes.
Key facts
- Study ID
- NCT03615235
- Run by
- Wake Forest University Health Sciences
- People needed
- 5000
- Starts
- 2019-03-21
- Expected to finish
- 2027-05-30
- Last updated by the study team
- 2026-05-26
Who can join
Age: any. Sex: any. Healthy volunteers: not accepted.
Where it is running
- University of Alabama at Birmingham — Birmingham, Alabama, United States
- University of California San Francisco — San Francisco, California, United States
- University of Miami / Miami Transplant Institute — Miami, Florida, United States
- Emory University School of Medicine — Atlanta, Georgia, United States
- University of Maryland School of Medicine — Baltimore, Maryland, United States
- Johns Hopkins University — Baltimore, Maryland, United States
- Joslin Diabetes Center / Harvard University — Boston, Massachusetts, United States
- University of Michigan Medicine — Ann Arbor, Michigan, United States
- Saint Louis University Center for Transplantation — St Louis, Missouri, United States
- Ichan School of Medicine at Mount Sinai — New York, New York, United States
- Columbia University Irving Medical Center — New York, New York, United States
- Weill Cornell Medicine — New York, New York, United States
- Duke University — Durham, North Carolina, United States
- Wake Forest School of Medicine — Winston-Salem, North Carolina, United States
- Cleveland Clinic — Cleveland, Ohio, United States
- University of Pennsylvania — Philadelphia, Pennsylvania, United States
- Vanderbilt University Medical Center — Nashville, Tennessee, United States
- University of Wisconsin - Madison — Madison, Wisconsin, United States
Full record on ClinicalTrials.gov
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