Static Lung Hyperinflation and Sympathetic Nerve Activity-Associated Large Artery Stiffness in COPD Patients
Completed · Phase 4 · Has a placebo group
Conditions studied: COPD
In brief
The goal of this study is to evaluate the acute effects of a long-acting bronchodilator on pulmonary function, vascular function and muscle sympathetic nerve activity in individuals with COPD. Individuals will be recruited from previous pulmonary research cohorts at The University of Iowa hospitals and clinics. Individuals that are interested in the study and are deemed eligible to participate will have a total of 3 visits to the laboratory, which includes the screening and consent (visit 1) that will last approximately 1 hour. Visits 2 and 3 are experimental visits and will be more extensive (\~4 hours). Participants will be randomized to receive either a long-acting bronchodilator or a placebo inhaler at the first experimental visit, followed by either the placebo inhaler or the long-acting bronchodilator at the second experimental visit. Assessments of pulmonary function, vascular function (via non-invasive, well-established techniques), and muscle sympathetic nerve activity will be performed at both experimental visits.
Key facts
- Study ID
- NCT03611699
- Run by
- Gary L. Pierce
- People needed
- 15
- Starts
- 2019-01-24
- Expected to finish
- 2020-04-01
- Last updated by the study team
- 2020-07-14
Who can join
Age: 30 and older, up to 80. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Age 30-80
- Ability to comfortably lie flat for 2 hours
- Normal/corrected hearing and vision
- English speaking
- Airway predominate phenotype of COPD
You may not qualify if…
- Other concomitant respiratory disorder (including asthma)
- Use of antibiotics or steroids for a COPD exacerbation within the past month
- Use of 24-hour oxygen
- Pregnancy or suspected pregnancy
- Uncontrolled cancer within the last 5 years
- Radiation therapy to the chest
- Lung surgery (LVRS, transplant, lobectomy)
- Lung cancer known or suspected
- Insulin-dependent diabetes
- Inability to use an inhaler bronchodilator
- Eye surgery in the last 5 weeks
- Chest or abdominal surgery in the past 3 months
- Heart attack in the last 3 months
- Hospitalization for any heart problem in the past month
- Renal failure
- Heart failure
- Substance use disorder
- Cystic fibrosis
- Glaucoma
- Prostate disorder
- Allergy to milk or milk products
- Cardiac arrhythmia
- Currently using a LAMA/LABA combination bronchodilator
Where it is running
- The University of Iowa Hospital and Clinics — Iowa City, Iowa, United States
Full record on ClinicalTrials.gov
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