Effect of Moderate Caloric Restriction on Glomerular Growth After Kidney Transplantation

Stopped early · Not applicable

Conditions studied: Kidney Transplant; Complications, Glomerular Disease, Weight Gain, Kidney Transplant

In brief

One possible reason that weight gain after transplant may interfere with new kidney function is due to the enlargement of a kidney structure called the glomerulus. The researchers believe that modest caloric intake reduction (CIR) early after kidney transplantation can reduce the enlargement (hypertrophy) of the glomerulus associated with kidney transplantation and may improve long term allograft survival, by reducing glomerular hypertrophy mediated progressive glomerulosclerosis.

Key facts

Study ID

NCT03607500

Run by

University of Michigan

People needed

1

Starts

2019-08-22

Expected to finish

2021-08-16

Last updated by the study team

2023-02-08

Who can join

Age: 18 and older, up to 70. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Recipients of kidney transplants where a post perfusion biopsy is obtained
• Body Mass Index between 25-30 kg/m2 at the time of randomization
• Non-diabetic
• Have a smart phone or active internet connection at home

You may not qualify if…

• Patients on dual anti platelet agents or are on oral anti coagulation medication
• Patients who have had Bariatric Surgery

Where it is running

• The University of Michigan — Ann Arbor, Michigan, United States

Full record on ClinicalTrials.gov

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