A Study to Evaluate Upadacitinib in Adolescents and Adults With Moderate to Severe Atopic Dermatitis (Measure Up 2)

Completed · Phase 3 · Has a placebo group

Conditions studied: Atopic Dermatitis

In brief

The objective of this study is to assess the efficacy and safety of upadacitinib for the treatment of adolescent and adult participants with moderate to severe atopic dermatitis (AD) who are candidates for systemic therapy.

Key facts

Study ID

NCT03607422

Run by

AbbVie

People needed

912

Starts

2018-07-27

Expected to finish

2025-11-11

Last updated by the study team

2026-06-02

Who can join

Age: 12 and older, up to 75. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Body weight of ≥ 40 kg at Baseline Visit for participants ≥ 12 and < 18 years of age
• Chronic atopic dermatitis (AD) with onset of symptoms at least 3 years prior to Baseline and subject meets Hanifin and Rajka criteria
• Active moderate to severe AD defined by Eczema Area and Severity Index (EASI) ≥ 16, validated Investigator's Global Assessment (vIGA) ≥ 3, body surface area (BSA) affected by AD ≥ 10%, and weekly average of daily Worst Pruritus numerical rating scale (NRS) score ≥ 4.
• Candidate for systemic therapy or have recently required systemic therapy for AD
• Documented history (within 6 months prior to Baseline) of inadequate response to topical corticosteroid (TCS) or topical calcineurin inhibitor (TCI) or documented systemic treatment for AD or for whom topical treatments are otherwise medically inadvisable due to side effects or safety risks

You may not qualify if…

• Prior exposure to any Janus kinase (JAK) inhibitor
• Unable or unwilling to discontinue current AD treatments prior to the study
• Requirement of prohibited medications during the study
• Other active skin diseases or skin infections requiring systemic treatment or would interfere with appropriate assessment of atopic dermatitis lesions
• Female subject who is pregnant, breastfeeding, or considering pregnancy during the study

Where it is running

• Medical Dermatology Specialist /ID# 205516 — Phoenix, Arizona, United States
• Arizona Research Center, Inc. /ID# 205795 — Phoenix, Arizona, United States
• The Dermatology Clinic of Arkansas /ID# 218749 — Bryant, Arkansas, United States
• Arkansas Research Trials /ID# 218469 — North Little Rock, Arkansas, United States
• Encino Research Center /ID# 207472 — Encino, California, United States
• University of California Irvine /ID# 205136 — Irvine, California, United States
• Ark Clinical Research /ID# 218193 — Long Beach, California, United States
• Keck School of Medicine of USC /ID# 206971 — Los Angeles, California, United States
• Wallace Medical Group /ID# 205701 — Los Angeles, California, United States
• Child Hosp of Orange County,CA /ID# 205735 — Orange, California, United States
• Palmtree Clinical Research Inc. /Id# 206184 — Palm Springs, California, United States
• Rady Children's Hospital San Diego /ID# 208244 — San Diego, California, United States
• Southern California Derma. Inc /ID# 205734 — Santa Ana, California, United States
• Innovative Clinical Research - Lafayette /ID# 208400 — Lafayette, Colorado, United States
• New England Research Associates, LLC /ID# 206896 — Bridgeport, Connecticut, United States
• Ideal Clinical Research Inc. /ID# 209880 — Aventura, Florida, United States
• Skin Care Research, LLC /ID# 207099 — Boca Raton, Florida, United States
• Midflorida Clinical Research, Inc. /ID# 213700 — Brandon, Florida, United States
• Clinical Research of West Florida, Inc /ID# 206146 — Clearwater, Florida, United States
• Revival Research /ID# 208383 — Doral, Florida, United States
• Universal Axon Clinical Research /ID# 213703 — Doral, Florida, United States
• Lakes Research, LLC /ID# 209156 — Miami, Florida, United States
• Miami Dade Medical Research Institute /ID# 209413 — Miami, Florida, United States
• Savin Medical Group, LLC /ID# 206902 — Miami Lakes, Florida, United States
• Total Skin and Beauty Derm Ctr /ID# 205129 — Birmingham, Alabama, United States

Full record on ClinicalTrials.gov

Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.