The Influence of Oral Probiotics on the Microbiome and Lipidome

Completed · Not applicable · Has a placebo group

Conditions studied: Gut Microbiome, Skin Microbiome, Gut Lipidome, Skin Lipidome, Blood Lipidome

In brief

The purpose of this study is to measure oil production of the face, facial properties, and gut bacteria in people being given oral probiotics. Probiotic supplements contain active cultures of bacteria that are thought to be beneficial to human health.The investigators want to find out if probiotics taken by mouth alter the bacteria in subject's gut and subject's skin oil production compared to a placebo. This is a single blind study and subject may receive a probiotic or a placebo for the first half of the study and a placebo or a probiotic for the second half of the study. Subject will not know what was given to participants.

Key facts

Study ID

NCT03605108

Run by

University of California, Davis

People needed

25

Starts

2018-06-29

Expected to finish

2019-05-09

Last updated by the study team

2019-06-12

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• 18 years of age or older

You may not qualify if…

• Those on oral antibiotics within a month of initiating the study.
• Subjects must have no history of diabetes, known cardiovascular disease, known immunocompromised condition, malignancy, kidney disease, or chronic steroid use.
• Subjects must have no history or diagnosis of gastrointestinal inflammatory diseases.
• Those with BMI higher than 30 kg/m²
• Those on topical medications to the face such as retinoids or antibiotics who are not willing or medical unable (in the judgement of the investigator) to discontinue use for two weeks prior to the study and for the duration of study participation.
• Those that have undergone a change in hormonally based therapies, such as but not limited to oral contraceptive pills or progesterone based pills within the last two months. Progesterone releasing IUDs are considered hormone releasing therapy.
• Use of medications that alter blood lipids, such as statins and anti-hyperlipidemic medications
• Current tobacco smokers, OR those that have smoked tobacco over the past year, OR a 5 year-pack year history of smoking tobacco
• Pregnant women
• Prisoners
• Adults unable to consent

Where it is running

• UC Davis Department of Dermatology — Sacramento, California, United States

Full record on ClinicalTrials.gov

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